Circulating tumor cells measurements in hepatocellular carcinoma.
Circulating tumor cells measurements in hepatocellular carcinoma.
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DOI：
10.1155/2012/684802
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发表时间：
2012
影响因子：
1.8
通讯作者：
Chiappini F
中科院分区：
文献类型：
--
作者：
Chiappini F
肝癌是男性第五大常见癌症，女性第七大常见癌症。在过去的20年中，HCC的发病率增加了两倍，而5年生存率仍低于12%。循环肿瘤细胞（CTC）的存在反映了肿瘤的侵袭性。已经进行了许多尝试来开发在HCC发展期间可靠地检测和计数CTC的测定法。在这种情况下，挑战是（1）对HCC（肿瘤细胞与非肿瘤细胞）具有特异性的标志物很少，（2）它们可用于定量血流中CTC的数量。另一个技术挑战包括发现与数百万白细胞和数十亿红细胞混合的少量CTC。CTC检测和鉴定可用于估计预后，并可作为评估治疗抗肿瘤活性的早期标志物。CTC还可用于预测无进展生存期和总生存期。CTC是一个有趣的生物信息来源，以了解传播，耐药性和治疗诱导的细胞死亡。我们的目的是回顾和分析现有的不同的新方法来检测，计数和描述肝癌患者外周循环中的CTC。
Liver cancer is the fifth most common cancer in men and the seventh in women. During the past 20 years, the incidence of HCC has tripled while the 5-year survival rate has remained below 12%. The presence of circulating tumor cells (CTC) reflects the aggressiveness nature of a tumor. Many attempts have been made to develop assays that reliably detect and enumerate the CTC during the development of the HCC. In this case, the challenges are (1) there are few markers specific to the HCC (tumor cells versus nontumor cells) and (2) they can be used to quantify the number of CTC in the bloodstream. Another technical challenge consists of finding few CTC mixed with million leukocytes and billion erythrocytes. CTC detection and identification can be used to estimate prognosis and may serve as an early marker to assess antitumor activity of treatment. CTC can also be used to predict progression-free survival and overall survival. CTC are an interesting source of biological information in order to understand dissemination, drug resistance, and treatment-induced cell death. Our aim is to review and analyze the different new methods existing to detect, enumerate, and characterize the CTC in the peripheral circulation of patients with HCC.