SHORT-TERM SELECTION FOR RECOMBINATION AMONG MUTUALLY ANTAGONISTIC SPECIES
SHORT-TERM SELECTION FOR RECOMBINATION AMONG MUTUALLY ANTAGONISTIC SPECIES
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DOI：
10.1038/328066a0
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发表时间：
1987-07-02
期刊：
影响因子：
64.8
通讯作者：
SMITH, JM
中科院分区：
文献类型：
--
作者：
BELL, G;SMITH, JM
在一个统一的和可预测的环境中，单一的多位点基因型是最佳的，基因重组显然是不利的。但异质性或不可预测性并不一定意味着重组的短期优势，只有当环境中具有适应性的重要特征之间的相关性频繁变化时，重组才会产生。另一种表达这一结论的方式是，只有当选择往往有利于改变连锁（配子期）不平衡的标志时，导致非零重组率的基因才会倾向于传播。因为很难想象自然环境经常以这种方式表现，最近关于性别维持、重组和异交的理论工作推测生物相互作用可能很重要3 - 5。May和anderson 6分析了宿主和寄生虫共同进化的双位点单倍体模型，与本文所考虑的相似，结果表明，有重组的群体的平均适应度通常高于没有重组的群体，尽管他们没有明确考虑影响重组的基因频率的变化。Hutson和law7和bell8认为，物种间拮抗相互作用的关键特征是基因型在前几代中出现频率对当前适应度的影响；这种时间滞后的频率依赖选择倾向于破坏基因型频率和连锁不平衡，其振荡已被证明在显式遗传模型中促进高重组等位基因的传播8。在本文中，我们将展示两个物种的相互对抗如何导致一个循环博弈，在一个完全定义的遗传模型中，高重组等位基因可以具有很大的短期选择优势。
The recombination of genes is clearly disadvantageous in a uniform and predictable environment where a single multilocus genotype is optimal. But heterogeneity or unpredictability do not necessarily imply a short-term advantage for recombination, which will be created only if the correlation between adaptively important features of the environment frequently changes sign1. Another way of expressing this conclusion is to say that genes causing non-zero rates of recombination will tend to spread only if selection often favours a change in the sign of linkage (gametic phase) disequilibrium2. Because it is difficult to imagine that the physical environ-ment often behaves in this fashion, recent theoretical work on the maintenance of sex, recombination and outcrossing has speculated that biotic interactions may be important3–5. May and Anderson6analysed a two-locus haploid model of the coevolution of host and parasite, similar to that considered here, and showed that the mean fitness of a population with recombination is typically higher than that of a population without, although they did not explicitly consider changes in the frequency of genes affecting recombination. Hutson and Law7and Bell8suggested that the crucial feature of antagonistic interactions between species is the effect on the current fitness of a genotype of its frequency in previous generations; such time-lagged frequency-dependent selection tends to destabilize both genotype frequencies and linkage disequilibrium, whose oscillation has been shown to fuel the spread of high-recombination alleles in explicit genetic models8. In this paper, we shall show how the mutual antagonism of two species can lead to a cyclical game in which high-recombination alleles can have a large short-term selective advantage in a fully defined genetic model.