Black hairy tongue after chemotherapy for malignant brain tumors
Black hairy tongue after chemotherapy for malignant brain tumors
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恶性脑肿瘤化疗后舌头发黑
DOI：
10.1007/s00701-016-3036-5
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发表时间：
2017
期刊：
影响因子：
2.4
通讯作者：
and Nagane M
中科院分区：
文献类型：
--
作者：
Yamagishi Y;Maruyama K;Kobayashi K;Kume S;Sasaki N;Yokoya S;Saito K;Shiokawa Y;and Nagane M
192例接受化疗的脑肿瘤患者中有5例出现黑毛舌(BHT)，发生率为2.6%。3名有糖尿病病史的患者在化疗开始后10天内出现了BHT。另2例患者在诱导后超过100天，3级或更严重的淋巴细胞减少超过20天，这在3例糖尿病患者中没有观察到。我们发现，恶性脑肿瘤化疗后可发生BHT。糖尿病患者化疗后早期出现，而长期严重淋巴细胞减少的患者出现在晚期。
Black hairy tongue (BHT) developed in five patients (2.6%) among 192 patients undergoing chemotherapy for malignant brain tumors. Three patients with a history of diabetes mellitus developed BHT within 10 days after the initiation of chemotherapy. The other two patients suffered more than 100 days after induction and lymphopenia of grade 3 or worse developed for more than 20 days, which was not observed in the three patients with diabetes. We found that BHT could develop after chemotherapy for malignant brain tumors. Patients with diabetes mellitus presented early after chemotherapy, while patients with longstanding severe lymphopenia presented in late phase.