Infection of U937 monocytic cells with Chlamydia pneumoniae induces extensive changes in host cell gene expression.
Infection of U937 monocytic cells with Chlamydia pneumoniae induces extensive changes in host cell gene expression.
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肺炎衣原体感染 U937 单核细胞会引起宿主细胞基因表达的广泛变化。
DOI：
10.1086/379047
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Showe,LouiseC
中科院分区：
文献类型：
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作者：
Virok,Dezso;Loboda,Andrey;Kari,Laszlo;Nebozhyn,Michael;Chang,Celia;Nichols,Calen;Endresz,Valeria;Gonczol,Eva;Berencsi,Klara;Showe,MichaelK;Showe,LouiseC
应用补体基因芯片研究了肺炎衣原体感染对人单核细胞信使RNA表达的影响。这些数据记录了一系列影响128个基因的转录事件，其中许多基因以前没有报道过受到C。肺炎感染下调的基因主要与RNA和DNA代谢、染色体稳定性和细胞周期调控相关。上调的信息包括具有重要促炎功能的各种基因的信息。许多上调的基因-包括透明质酸受体CD 44、血管收缩因子内皮素-1、平滑肌生长因子肝素结合EGF样生长因子和脂肪酸结合蛋白-4-先前已被描述为与动脉粥样硬化和其他慢性炎症性疾病的发展有关。肺炎感染的单核细胞可促进急性或慢性炎症已被证明是重要的疾病的发展和进展，如动脉粥样硬化
The effect of infection withChlamydia pneumoniaeon host messenger RNA expression in human monocytic cells with complement DNA microarrays was studied. The data chronicle a cascade of transcriptional events affecting 128 genes, many of which have not previously been reported to be affected byC. pneumoniaeinfection. Down-regulated genes are primarily associated with RNA and DNA metabolism, chromosomal stability, and cell-cycle regulation. Up-regulated messages include those for a variety of genes with important proinflammatory functions. Many of the up-regulated genes—including the hyaluron receptor CD44, vasoconstrictor endothelin-1, smooth muscle growth factor heparin-binding EGF-like growth factor, and fatty acid binding protein–4—had been previously described as linked to the development of atherosclerosis and other chronic inflammatory diseases.C. pneumoniae–infected monocytes can contribute to the development and progression of diseases for which acute or chronic inflammation has been shown to be important, such as atherosclerosis