Application of clinical indices of fetal growth and wellbeing to a novel laboratory species, the spiny mouse
Application of clinical indices of fetal growth and wellbeing to a novel laboratory species, the spiny mouse
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DOI：
10.1016/s1642-431x(12)60014-x
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发表时间：
2008-11-01
影响因子：
2.1
通讯作者：
Jenkin, Graham
中科院分区：
文献类型：
--
作者：
Dickinson, Hayley;Griffiths, Tania;Jenkin, Graham
在整个妊娠期间，使用超声波测量多刺小鼠胎儿的生长，并记录心率和脐带血流量的多普勒测量值，以监测胎儿的血液供应和健康状况。在整个妊娠期间，将雌性多刺小鼠麻醉6次。使用Philips HDI 5000机器使用紧凑型线性CL 15 -7换能器进行超声检查。胎心率和生长参数在整个妊娠期增加。通过脐动脉和静脉的血流显示出在妊娠期增加的速度，并降低阻力指数。通过静脉导管的血流速度也在妊娠期增加，但阻力指数保持不变。我们已经确定了多刺小鼠在整个妊娠过程中脐血流的变化，这与人类妊娠中所见的相似。我们还证实，超声波可以作为一种有价值的，非侵入性的技术，用于测量胎儿的生长和健康的多刺小鼠。生殖生物学2008，8，3：229-243.
Ultrasound was used to measure growth of the spiny mouse fetus throughout gestation and to record Doppler measurements of heart rate and umbilical blood flow to monitor fetal blood supply and wellbeing. Female spiny mice were anesthetized on 6 occasions throughout pregnancy. Ultrasound was performed with a Philips HDI 5000 machine using a compact lineai CL15-7 transducer. Fetal heart rate and growth parameters increased across gestation. Blood flow through the umbilical artery and vein showed increasing velocity over gestation, and reduced resistance index. Blood flow through the ductus venosus also increased in velocity over gestation; however the resistance index remained constant. We have determined changes in umbilical blood flow throughout pregnancy in the spiny mouse, which resemble those seen in human pregnancy. We also confirm that ultrasound can be used as a valuable, non-invasive technique for measuring fetal growth and wellbeing in the spiny mouse. Reproductive Biology 2008, 8, 3:229-243.