Effect of Gelatin Hydrogel Containing BMP-2 on Bone Formation in Aged Rats
Effect of Gelatin Hydrogel Containing BMP-2 on Bone Formation in Aged Rats
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含BMP-2的明胶水凝胶对老年大鼠骨形成的影响
DOI：
10.11223/jarde.19.10
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Yoshiyama Masahiro
中科院分区：
文献类型：
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作者：
Yamaji Kozo;Yokoyama Akihito;Matsuzaki Kumiko;Ohara Naoko;Sugaya Tsutomu;Yoshiyama Masahiro
本研究旨在研究含骨形态发生蛋白-2（BMP-2）的生物可降解明胶水凝胶（Gel）对10周龄（10周龄组）和70周龄（70周龄组）雄性Wistar大鼠腭部骨膜下骨形成的影响。两个年龄组的实验部位分为两个植入体：含BMP-2的凝胶（BMP部位）和仅含凝胶（凝胶部位）。植入4周后，各部位均有新骨形成，BMP部位的新骨厚度（TNB）明显大于Gel部位（p< 0.05）。10周组各实验部位的TNB均显著高于70周组同一实验部位的TNB（p< 0.05）。
This study was designed to examine the effect of biodegradable gelatin hydrogel (Gel) containing bone morphogenetic protein-2 (BMP-2) on bone formation at palatal subperiosteal sites in 10-week-old (10w group) and 70-week-old (70w group) male Wistar rats. The experimental sites of both age groups were divided into two implants: Gel containing BMP-2 (BMP site) and Gel only (Gel site). Four weeks after implantation, new bone formation was observed at every site and the thickness of new bone (TNB) of the BMP site was significantly greater than that of the Gel site of both age groups (p< 0.05). The TNB of every site in the 10w group was significantly greater than that of the same experimental site in the 70w group (p< 0.05).