Flash and pattern electroretinograms in normal and laser-induced glaucomatous primate eyes.
Flash and pattern electroretinograms in normal and laser-induced glaucomatous primate eyes.
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发表时间：
1986-03
影响因子：
4.4
通讯作者：
M. Marx;S. Podos;I. Bodis-Wollner;J. Howard-Williams;M. Siegel;C. Teitelbaum;E. Maclin;C. Severin
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文献类型：
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作者：
M. Marx;S. Podos;I. Bodis-Wollner;J. Howard-Williams;M. Siegel;C. Teitelbaum;E. Maclin;C. Severin
用氩激光以1200-1500 mW的功率和0.5秒至360度的中小梁网传递100-200个50 μ点，在5只食蟹猴的一只眼睛中产生实验性青光眼。在激光治疗前和治疗后2、3和4个月记录单眼视网膜电图（ERG）。在激光治疗（青光眼）的眼睛，正常的闪光ERG观察使用1 Hz的刺激，但是，模式ERG（PERG）引起的使用稳态反相调制的0.51 cpd方波光栅显示统计学上显着的幅度降低。使用1.25 cpd光栅时，仅观察到PERG振幅的小幅降低。在3只动物中，PERG异常发生在视神经头临床显著杯状突出之前。此外，PERG振幅的降低是进行性的，并且与视神经乳头的杯状变化幅度和眼内压升高相关。PERG振幅在青光眼眼的眼内压急性降低后没有变化。进行了几个对照实验，以确保结果不是由于青光眼眼睛的瞳孔大小、屈光状态或调节的改变。作者相信他们现在有了一个用于青光眼电生理研究的猴子模型。
Experimental glaucoma was produced in one eye of five cynomolgus monkeys with the argon laser delivering 100-200 50-mu spots at 1200-1500 mW power and 0.5 sec to 360 degrees of the mid-trabecular meshwork. Monocular electroretinograms (ERGs) were recorded prior to and 2, 3, and 4 mo following the laser treatment. In the laser-treated (glaucoma) eyes, normal flash ERGs were observed using 1-Hz stimulation; however, pattern ERGs (PERGs) elicited using steady-state counterphase modulation of a 0.51 cpd square wave grating showed statistically significant reductions of amplitude. Only small reductions of PERG amplitude were seen with a 1.25 cpd grating. In three animals, abnormalities of the PERG occurred prior to clinically significant cupping of the optic nervehead. Moreover, reductions of PERG amplitude were progressive and associated with the magnitude of cupping of the optic nervehead and elevation of intraocular pressure. PERG amplitude did not change following acute reductions in intraocular pressure in the glaucoma eyes. Several control experiments were conducted to insure that results were not due to alterations in pupil size, refractive state, or accommodation in the glaucoma eyes. The authors believe they now have a monkey model for the electrophysiologic study of glaucoma.