Effects of neurosecretory protein GL on food intake and fat accumulation under different dietary nutrient compositions in rats
Effects of neurosecretory protein GL on food intake and fat accumulation under different dietary nutrient compositions in rats
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DOI：
10.1093/bbb/zbab064
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发表时间：
2021-04-14
影响因子：
1.6
通讯作者：
Ukena, Kazuyoshi
中科院分区：
文献类型：
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作者：
Fukumura, Keisuke;Shikano, Kenshiro;Ukena, Kazuyoshi
我们最近发现了一种新型下丘脑小蛋白，称为神经分泌蛋白 GL (NPGL)，它参与鸟类和哺乳动物的能量稳态。然而，NPGL 的作用是否受到营养成分的影响仍不清楚。因此，我们研究了在正常饲料（NC）饮食、高脂饮食、高糖饮食（HSD）和中脂/中蔗糖饮食（MFSD）下，慢性侧脑室内输注 NPGL 13 天对大鼠摄食行为和体重增加的影响。 NPGL 刺激 NC 和 MFSD 的食物摄入，尤其是在光照期间。相比之下，在 NC 喂养下，NPGL 降低了体重增加，并增加了 HSD 和 MFSD 喂养大鼠的总白色脂肪组织质量。这些数据表明，NPGL 对摄食行为、体重增加和脂肪积累的影响取决于营养类型。其中，饮食中的蔗糖似乎有助于 NPGL 引起的脂肪积累。
We recently identified a novel hypothalamic small protein, named neurosecretory protein GL (NPGL), which is involved in energy homeostasis in birds and mammals. However, whether the action of NPGL is influenced by nutritional composition remains unknown. Thus, we investigated the effect of chronic intracerebroventricular infusion of NPGL for 13 days on feeding behavior and body mass gain under a normal chow (NC) diet, high-fat diet, high-sucrose diet (HSD), and medium-fat/medium-sucrose diet (MFSD) in rats. NPGL stimulated food intake of NC and MFSD, especially during the light period. By contrast, NPGL decreased body mass gain under NC and increased total white adipose tissue mass in HSD- and MFSD-fed rats. These data suggest that the effects of NPGL on feeding behavior, body mass gain, and fat accumulation depend on nutrient type. Among them, sucrose in diets seems to contribute to fat accumulation elicited by NPGL.