Prothrombin and Factor X Are Elevated in Multiple Sclerosis Patients
Prothrombin and Factor X Are Elevated in Multiple Sclerosis Patients
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DOI：
10.1002/ana.24807
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发表时间：
2016-12-01
影响因子：
11.2
通讯作者：
Meuth, Sven G.
中科院分区：
文献类型：
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作者：
Goebel, Kerstin;Kraft, Peter;Meuth, Sven G.
动物模型暗示了凝血因子在神经炎性疾病如多发性硬化症（MS）中的不可或缺的作用，而不仅仅是它们在止血中的作用。然而，其在人类中的相关性需要进一步阐明。本研究旨在确定神经免疫性疾病患者和相应对照组之间的凝血因子水平是否存在差异。复发缓解型和继发性进展型MS患者的凝血酶原和因子X水平显著高于健康供体，而原发性进展型MS和视神经肌萎缩患者的水平没有变化。我们的研究表明，凝血因子可能是神经炎症的关键介质，因此可能提供未来的治疗策略的目标。
Animal models have implicated an integral role for coagulation factors in neuroinflammatory diseases such as multiple sclerosis (MS) beyond their role in hemostasis. However, their relevance in humans requires further elucidation. This study aimed to determine whether levels of coagulation factors differ between patients with neuroimmunological disorders and respective controls. Individuals suffering from relapsing-remitting and secondary progressive MS had significantly higher prothrombin and factor X levels than healthy donors, whereas levels were unchanged in primary progressive MS and neuromyelitis optica patients. Our study demonstrates that coagulation factors may be key mediators in neuroinflammation and may therefore provide future targets for therapeutic strategies.