The prognostic value of the QT interval and QT interval dispersion in all-cause and cardiac mortality and morbidity in a population of Danish citizens
The prognostic value of the QT interval and QT interval dispersion in all-cause and cardiac mortality and morbidity in a population of Danish citizens
复制标题
DOI：
10.1053/euhj.1998.1094
复制
发表时间：
1998-09-01
影响因子：
39.3
通讯作者：
Camm, J
中科院分区：
文献类型：
--
作者：
Elming, H;Holm, E;Camm, J
目标。评价QT间期和QT间期离散度在一般人群中对总死亡率和心血管死亡率以及心脏发病率的预后价值。方法与结果。随机选取年龄在30-60岁之间的1658名女性和1797名男性，测量所有标准12导联心电图导联的QT间期。QT间期离散度由任意两个导联的最大QT间期差计算。13年以上的全因死亡率、11年以上的心血管死亡率和心脏发病率是主要的结局参数。QT间期延长（430 ms或更长）或QT间期离散度延长（80 ms或更长）的受试者比QT间期小于360 ms或QT间期离散度小于30 ms的受试者有更高的心血管死亡和心脏发病率风险。经年龄、性别、心肌梗死、心绞痛、糖尿病、动脉高血压、吸烟习惯、血清胆固醇水平和心率调整后的心血管死亡相对风险比在QT间期为29(95%可信区间1.1-7.8)，在QT间期离散度为4.4（95%可信区间1.0-19.1）。致死性和非致死性心脏发病率的相对风险比相似，QT间期为2.7(95%可信区间1.4-5.5)，QT间期离散度为2.2（95%可信区间1.1-4.0）。QT间期延长和QT间期离散度独立影响普通人群心血管死亡率和心脏致死性和非致死性发病率的预后。
Aims. To evaluate the prognostic value of the QT interval and QT interval dispersion in total and in cardiovascular mortality, as well as in cardiac morbidity, in a general population.Methods and results. The QT interval was measured in all leads from a standard 12-lead ECG in a random sample of 1658 women and 1797 men aged 30-60 years. QT interval dispersion was calculated from the maximal difference between QT intervals in any two leads. All cause mortality over 13 years, and cardiovascular mortality as well as cardiac morbidity over 11 years, were the main outcome parameters. Subjects with a prolonged QT interval (430 ms or more) or prolonged QT interval dispersion (80 ms or more) were at higher risk of cardiovascular death and cardiac morbidity than subjects whose QT interval was less than 360 ms, or whose QT interval dispersion was less than 30 ms. Cardiovascular death relative risk ratios, adjusted for age, gender, myocardial infarct, angina pectoris, diabetes mellitus, arterial hypertension, smoking habits, serum cholesterol level, and heart rate were 29 for the QT interval (95% confidence interval 1.1-7.8) and 4.4 for QT interval dispersion (95% confidence interval 1.0-19.1). Fatal and non-fatal cardiac morbidity relative risk ratios were similar, at 2.7 (95% confidence interval 1.4-5.5) for the QT interval and 2.2 (95% confidence interval 1.1-4.0) for QT interval dispersion.Conclusion. Prolongation of the QT interval and QT interval dispersion independently affected the prognosis of cardiovascular mortality and cardiac fatal and non-fatal morbidity in a general population over Il years.