Associations Between RASSF1A Promoter Methylation and NSCLC: A Meta-analysis of Published Data
Associations Between RASSF1A Promoter Methylation and NSCLC: A Meta-analysis of Published Data
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DOI：
10.7314/apjcp.2013.14.6.3719
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发表时间：
2013-01-01
影响因子：
--
通讯作者：
Cen, Hong
中科院分区：
文献类型：
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作者：
Liu, Wen-Jian;Tan, Xiao-Hong;Cen, Hong
背景：RASSF 1A已被报道是非小细胞肺癌（NSCLC）的候选肿瘤抑制因子。然而，RASSF 1A启动子甲基化与NSCLC之间的关系仍不清楚，特别是与临床病理特征的关系。研究方法：通过检索PubMed、EMBASE、科克伦图书馆和中国知网（CNKI）数据库确定合格的研究。汇总研究，计算比值比（OR）和相应的置信区间（CI）。还进行漏斗图以评价发表偏倚。结果：本荟萃分析纳入了19项研究，涉及2，063例NSCLC病例和1，184例对照。RASSF 1A基因甲基化与NSCLC的发生有显著相关性（OR = 19.42，95%CI：14.04-26.85，P
Background: RASSF1A has been reported to be a candidate tumor suppressor in non-small cell lung cancer (NSCLC). However, the association between RASSF1A promoter methylation and NSCLC remains unclear, particularly in regarding links to clinicopathologic features. Methods: Eligible studies were identified through searching PubMed, EMBASE, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases. Studies were pooled and odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated. Funnel plots were also performed to evaluate publication bias. Results: Nineteen studies involving 2,063 cases of NSCLC and 1,184 controls were included in this meta-analysis. A significant association was observed between RASSF1A methylation and NSCLC in the complete data set (OR = 19.42, 95% CI: 14.04-26.85, P