Effects of plane of nutrition on oxidative stress in goats during the peripartum period
Effects of plane of nutrition on oxidative stress in goats during the peripartum period
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DOI：
10.1016/j.tvjl.2009.01.014
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发表时间：
2010-04-01
影响因子：
2.2
通讯作者：
Claps, Salvatore
中科院分区：
文献类型：
--
作者：
Celi, Pietro;Di Trana, Adriana;Claps, Salvatore
本研究旨在监测高（HD; 140%的能量需求）与低饮食（LD; 80%的能量需求）对围产期山羊氧化状态的影响。在分娩后第2、1、0（分娩）、+2和+4周从所有山羊中采集血样。测定血液中活性氧代谢产物（ROMs）、巯基（SH）、总抗氧化能力（OXY）、谷胱甘肽过氧化物酶（GSH-Px）和超氧化物歧化酶（SOD）活性。在围产期期间ROM水平显著增加的观察伴随着GSH-Px活性在产后2周和4周的下降，这表明山羊可能经历了一定程度的氧化应激和脂质过氧化。总的来说，饮食营养水平的变化对氧化还原稳态的影响很小或没有影响。测量的生物标志物之间缺乏任何相关性表明，每个氧化应激标志物的反应不同，这表明这些奶山羊在围产期氧化还原稳态受损。皇冠版权所有（C）2009由爱思唯尔有限公司出版。保留所有权利。
This study aimed to monitor the effect of a high (HD; 140% of energy requirements) versus a low diet (LD; 80% energy requirements) on oxidative status in goats during the peripartum period. Blood samples were taken from all goats at 2, 1,0 (partum), +2 and +4 weeks from delivery. Blood samples were assayed for their content of reactive oxygen metabolites (ROMs), thiol (SH) groups, total antioxidant capacity (OXY) and for glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities. The observation that ROMs levels significantly increased during the peripartum period was accompanied by a decrease of GSH-Px activity at weeks 2 and 4 postpartum, which suggested that the goats might have experienced some degree of oxidative stress and lipid peroxidation. Overall, changes to the nutritional level of the diet had very little or no effect on redox homeostasis. The lack of any correlation between the biomarkers measured indicated that each oxidative stress marker responded differently, indicating that redox homeostasis was impaired in these dairy goats during the peripartum period. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.