THE TOXICITY OF ORALLY-ADMINISTERED DEOXYNIVALENOL (VOMITOXIN) IN RATS AND MICE
THE TOXICITY OF ORALLY-ADMINISTERED DEOXYNIVALENOL (VOMITOXIN) IN RATS AND MICE
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DOI：
10.1016/0278-6915(86)90321-2
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发表时间：
1986-09-01
影响因子：
4.3
通讯作者：
VESONDER, RF
中科院分区：
文献类型：
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作者：
ARNOLD, DL;MCGUIRE, PF;VESONDER, RF
在断奶雄性啮齿动物中进行了两项研究，试图更准确地确定脱氧雪腐镰刀菌醇（DON）的毒性作用。在一项持续约18周的喂养研究中，每组90只瑞士韦伯斯特衍生小鼠和50只spragule - dawley大鼠被喂食商业饲料（118 ppb DON），每组80只小鼠和50只大鼠被喂食“未受污染”的饮食（53 ppb DON）或受污染的饮食（6250 ppb DON），均以小麦为基础。在5周的灌胃研究中，将24窝5只瑞士韦氏衍生小鼠分为以下组：未处理对照组、溶剂对照组和3个处理组，分别给予0.75、2.5和7.5 mg DON/kg体重。饲喂试验中虽有中间死亡，但灌胃试验中给药7.5或2.5 mg/kg的动物在试验期间大部分死亡。两项研究对体重和血液学参数的影响表明，在所有测试水平上，DON都引起了一定程度的毒性。灌胃研究的组织病理学结果表明，DON对免疫系统有影响，同时也是一种胃肠道刺激物。
Two studies were conducted with weanling male rodents in an attempt to ascertain more precisely the toxic effects of deoxynivalenol (DON). Iin a feeding study of approximately 18-wk duration, groups of 90 Swiss-Webster derived mice and 50 Sprague-Dawley rats were fed a commercial chow (118 ppb DON), and groups of 80 mice and 50 rats were fed either an ''uncontaminated'' diet (53 ppb DON) or a contaminated diet (6250 ppb DON), both based on wheat. A 5 wk gavage study was also performed, in which 24 litters of 5 Swiss-Webster-derived mice were divided among the following groups: an untreated control group, a solvent control group, and three treated groups receivig 0.75, 2.5 or 7.5 mg DON/kg body weight. While there were interim kills in the feeding study, most of the animals given 7.5 or 2.5 mg/kg in the gavage study died during the test period. Effects on body weight and haematological parameters in both studies indicate that DON elicited some degree of toxicity at all levels tested. The histopathological findings from the gavage study suggest that DON had effects on the immune system as well as being a gastro-intestinal irritant.