Conserved mechanisms regulate outgrowth in zebrafish fins
Conserved mechanisms regulate outgrowth in zebrafish fins
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DOI：
10.1038/nchembio.2007.36
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发表时间：
2007-10-01
影响因子：
14.8
通讯作者：
Iovine, M. Katryn
中科院分区：
文献类型：
--
作者：
Iovine, M. Katryn
大小调控是一个基本的问题，在一个一般的战略一直是确定分子内的细胞生长和细胞增殖一直特别揭示，确定参与细胞生长和存活的细胞自主通路，并为了确定整体和形态的调节通路，实验评估了移植和移除的组织，以及外基因。这项工作提供了大量调控形成、生长和图案形成的分子机制。利用FIN，遗传、细胞和分子策略被用来跟踪FIN突变体的正常模式和生长。本文将重点介绍斑马鱼尾鳍再生过程中尾鳍的生长和分子调控，强调与其他系统的相似性。未来描述使用斑马鱼鳍来调节最终大小的机会。
Regulation of size is one of the fundamental problems in One general strategy has been to identify molecules for cell growth and cell proliferation within an has been particularly revealing, identifying cell-autonomous pathways involved in cell growth, survival and In order to identify pathways regulating overall and morphology, experiments have evaluated transplanted and removed tissues, and out genes. This work has provided a vast amount of identifying molecular mechanisms regulating formation, outgrowth, and pattern formation. Using fin, genetic, cellular and molecular strategies been employed to follow both normal patterns of and growth in fin mutants. This review will focus and molecular regulation of the outgrowth and of the zebrafish caudal fin during regeneration, emphasize similarities to other systems. Future describe opportunities using the zebrafish fin to underlying the regulation of final size.