ANISOTROPIC DIFFUSION IN HUMAN WHITE MATTER - DEMONSTRATION WITH MR TECHNIQUES INVIVO
ANISOTROPIC DIFFUSION IN HUMAN WHITE MATTER - DEMONSTRATION WITH MR TECHNIQUES INVIVO
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DOI：
10.1148/radiology.177.2.2217776
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发表时间：
1990-11-01
期刊：
影响因子：
19.7
通讯作者：
PIPE, JG
中科院分区：
文献类型：
--
作者：
CHENEVERT, TL;BRUNBERG, JA;PIPE, JG
在运动敏化梯度的两个方向上定量测量脑白质的灌注和分子扩散，以记录这些参数的各向异性。测量被定位到10倍。在左脑室体上方的左大脑半球有一个前后指向的10毫米组织柱。选择这个区域是因为白质纤维的方向性相对较高。在本研究中，5名健康志愿者均表现出较强的扩散各向异性。通常观察到双重或更大的各向异性，沿纤维方向的运动灵敏度与较高的扩散值相关。结合所有病例中两个梯度方向的数据，实体组织的扩散值为0.38倍。10-3 mm2/秒至1.12倍。10-3 mm2/sec，测量的灌注分数在2%-5%范围内（不包括脑脊液高度污染的区域）。很少或没有观察到灌注分数的各向异性；然而，灌注测量受到噪声的限制。数据的收集没有心脏门控使用的技术，提供良好的免疫力，以大量组织运动的伪影。
Quantitative measurements of perfusion and molecular diffusion were made in human white matter in two orientations of the motion-sensitization gradient to document anisotropy of these parameters. Measurements were localized to a 10 .times. 10-mm tissue column oriented in an anterior-to-posterior directed in the left cerebral hemisphere just above the body of the left ventricle. This region was selected because of the relatively high directionality of white matter fibers. In this study of five healthy volunteers, strong diffusion anisotropy was observed in all cases. Twofold or greater anisotropy was commonly observed, with the higher diffusion value associated with motion sensitivity along the fiber directions. By combining data from both gradient orientations in all cases, diffusion values of solid tissue ranged from 0.38 .times. 10-3 mm2/sec to 1.12 .times. 10-3 mm2/sec, and measured perfusion fractions were in the range of 2%-5% (excluding areas highly contaminated by cerebrospinal fluid). Little or no perfusion-fraction anisotropy was observed; however, perfusion measurements were limited by noise. Data were collected without cardiac gating by using a technique that offers good immunity to bulk tissue motion artifacts.