Relationships between EGFR Mutation Status of Lung Cancer and Preoperative Factors - Are they Predictive?
Relationships between EGFR Mutation Status of Lung Cancer and Preoperative Factors - Are they Predictive?
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DOI：
10.7314/apjcp.2014.15.2.657
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发表时间：
2014-01-01
影响因子：
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通讯作者：
Sakuma, Tsutomu
中科院分区：
文献类型：
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作者：
Usuda, Katsuo;Sagawa, Motoyasu;Sakuma, Tsutomu
背景：肺癌的表皮生长因子受体(EGFR)突变状态很重要，因为这意味着EGFR酪氨酸激酶抑制剂的治疗是必要的。这项前瞻性研究的目的是确定是否可以参照术前因素确定EGFR突变状态。材料和方法：148例肺癌患者，其中腺癌11例，鳞癌25例，其他细胞类型12例。分析每例肺癌患者术后EGFR基因突变情况。结果：突变型EGFR肺癌58例(突变型LC)，野生型肺癌90例(野生型LC)。突变型LC与野生型LC在性别、吸烟状况、胸部CT肿瘤最大直径、肿瘤阴影类型、临床分期等方面差异有统计学意义。仅在腺癌中检测到EGFR突变。突变型LC的最大标准摄取值(SUVmax：3.66+/-4.53)显著低于野生型LC(8.26+/-6.11)(P<0.05)。
Background: The epidermal growth factor receptor (EGFR) mutation status of lung cancer is important because it means that EGFR-tyrosine kinase inhibitor treatment is indicated. The purpose of this prospective study is to determine whether EGFR mutation status could be identified with reference to preoperative factors. Materials and Methods: One hundred-forty eight patients with lung cancer (111 adenocarcinomas, 25 squamous cell carcinomas and 12 other cell types) were enrolled in this study. The EGFR mutation status of each lung cancer was analyzed postoperatively. Results: There were 58 patients with mutant EGFR lung cancers (mutant LC) and 90 patients with wild-type EGFR lung cancers (wild-type LC). There were significant differences in gender, smoking status, maximum tumor diameter in chest CT, type of tumor shadow, clinical stage between mutant LC and wild-type LC. EGFR mutations were detected only in adenocarcinomas. Maximum standardized uptake value (SUVmax:3.66 +/- 4.53) in positron emission tomography-computed tomography of mutant LC was significantly lower than that (8.26 +/- 6.11) of wild-type LC (p