For Whom the Bell Tolls (and Nods): Spit-acular Saliva.
For Whom the Bell Tolls (and Nods): Spit-acular Saliva.
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丧钟为谁而鸣（并点头）：吐出尖利的唾液。
DOI：
10.1007/s40475-016-0072-4
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发表时间：
2016
影响因子：
5.4
通讯作者：
Pedra,JoaoHF
中科院分区：
文献类型：
--
作者：
Shaw,DanaK;Kotsyfakis,Michail;Pedra,JoaoHF
壁虱出现在白垩纪早期，是一种古老的食血性体外寄生虫，在世界范围内具有重要的兽医和公共卫生重要性。他们生活策略的成功可以部分归功于唾液。随着我们进入一个为生物应用收集大量数据集和结构成为可能的科学时代，我们建议理解支配扁虱生命周期的分子机制是可以掌握的。考虑到这一点，我们讨论了目前已知的关于Toll-like(TLR)和Nod-like(NLR)受体信号通路通过扁虱唾液蛋白的操纵，以及这些分子如何影响病原体传播。
Having emerged during the early part of the Cretaceous period, ticks are an ancient group of hematophagous ectoparasites with significant veterinary and public health importance worldwide. The success of their life strategy can be attributed, in part, to saliva. As we enter into a scientific era where the collection of massive data sets and structures for biological application is possible, we suggest that understanding the molecular mechanisms that govern the life cycle of ticks is within grasp. With this in mind, we discuss what is currently known regarding the manipulation of Toll-like (TLR) and Nod-like (NLR) receptor signaling pathways by tick salivary proteins, and how these molecules impact pathogen transmission.