Lifetime cumulative number of menstrual cycles and serum sex hormone levels in postmenopausal women
Lifetime cumulative number of menstrual cycles and serum sex hormone levels in postmenopausal women
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DOI：
10.1007/s10549-007-9574-z
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发表时间：
2008-03-01
影响因子：
3.8
通讯作者：
Peeters, Petra H. M.
中科院分区：
文献类型：
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作者：
Chavez-MacGregor, Mariana;van Gils, Carla H.;Peeters, Petra H. M.
目的终身累积月经周期数与乳腺癌发病风险相关。本研究的目的是探讨绝经后妇女性激素水平与这一指标的关系。方法对参加欧洲癌症与营养前瞻性调查的860名自然绝经后荷兰人进行横断面研究。使用关于月经初潮和绝经年龄、怀孕次数、母乳喂养、口服避孕药使用(OC)和规律模式的问卷数据计算终身累积月经周期数。激素测定包括雌酮(E_1)、雌二醇(E_2)、雄烯二酮、睾酮、性激素结合球蛋白(SHBG)和脱氢表雄烯二酮硫酸酯(DHEAS)。通过协方差分析来评估终生累积月经周期数与激素水平之间的关系。还研究了繁殖特性与激素水平的关系。对采血特征进行调整，包括年龄、绝经年限、体重指数、激素替代治疗使用、OC使用、吸烟习惯、饮酒和体力活动。结果一生累计周期数与SHBG相关；最低类别的参与者SHBG水平较高。在分离特征中，DHEAS和雄烯二酮在月经初潮时随着年龄的增加而显著增加，而雄烯二酮和睾酮在绝经时随着年龄的增加而下降。对于产次特征，SHBG水平随着活产次数的增加而升高。结论SHBG只与SHBG有关。因此，雌激素或雄激素的游离水平可能与估计的月经周期数有关，反映了终生接触卵巢激素的情况。
Objective Lifetime cumulative number of menstrual cycles is related to breast cancer risk. The aim of this study is to investigate the relation between this index and serum sex hormone levels in postmenopausal women.Methods Cross-sectional study including 860 naturally postmenopausal Dutch participants of the European Prospective Investigation into Cancer and Nutrition. Lifetime cumulative number of menstrual cycles was computed using questionnaire data on ages at menarche and menopause, number of pregnancies, breastfeeding, oral contraceptive use (OC) and regularity pattern. Measurements of hormones included estrone (E1), estradiol (E2), andostrenedione, testosterone, sex-hormone binding globulin (SHBG) and dehydroepiandrostenedione sulfate (DHEAS). The relation between the lifetime cumulative number of menstrual cycles and hormone levels was assessed using analysis of covariance. Relations between reproductive characteristics and hormone levels were also studied. Adjustments for characteristics at blood collection included age, years since menopause, BMI, hormone replacement therapy use, OC use, smoking habits, alcohol intake and physical activity were done.Results Lifetime cumulative number of cycles was related with SHBG; participants in the lowest category had higher SHBG levels. For the separate characteristics, DHEAS and androstenedione increased significantly with increasing age at menarche, while androstenedione and testosterone decreased with increasing age at menopause. For the parity characteristics, SHBG levels increased according to the number of live births.Conclusions Lifetime cumulative number menstrual cycles was related only to SHBG. Therefore, free levels of estrogens or androgens may be related to this number of menstrual cycles estimate, reflecting lifetime exposure to ovarian hormones.