HEPATITIS B VIRUS INFECTION IN TWO GAMBIAN VILLAGES
HEPATITIS B VIRUS INFECTION IN TWO GAMBIAN VILLAGES
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冈比亚两个村庄出现乙型肝炎病毒感染
DOI：
10.1016/s0140-6736(83)92477-7
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
I. McGregor
中科院分区：
文献类型：
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作者：
Hilton C. Whittle;K. Mclauchlan;A. Bradley;A. Ajdukiewicz;Colin R. Howard;Arie J. Zuckerman;I. McGregor
B型肝炎病毒感染的流行率在冈比亚两个邻近的村庄有明显的不同。在Manduar，62%的2-4岁儿童被感染，而在另一个村庄Keneba，这一年龄组中只有27%被感染。然而，在这两个村庄，很少有婴儿被感染，6个月以下的婴儿无一感染，58名6至12个月的婴儿中只有2名感染。B型肝炎表面抗原（HBsAg）的携带率很高，在Manduar的5-9岁年龄组中达到36%的高峰，在Keneba的2-4岁年龄组中达到17.6%。HBsAg阳性的5岁以下儿童中86%同时携带HBeAg。10-14岁儿童的这一比例降至17.6%，母亲的这一比例降至12.9%。感染有家族聚集性，主要为同胞间的传播。如果年长的兄弟姐妹携带抗原，儿童成为HBsAg携带者的可能性约为42%，如果母亲或父亲是携带者，则为27%，如果母亲或父亲都不是携带者，则为15%。有4个HBeAg阳性的母亲谁是高传染性，因为10的11个孩子成为HBsAg携带者。表面抗原的携带持续了许多年，1972年携带抗原的人中有63%在1980年末仍呈阳性。在过去的五年中，672例成人中有4例原发性肝细胞癌被诊断出来。4例均为HBsAg携带者。
The prevalence of hepatitis B virus infection was markedly different in two neighbouring Gambian villages. 62% of children in Manduar aged 2–4 years were infected whereas in Keneba, the other village, only 27% of this age-group were infected. However, in both villages few infants were infected-none under 6 months of age and only 2 of 58 between the ages of 6 and 12 months. Carriage of hepatitis B surface antigen (HBsAg) was high, reaching a peak of 36% in the 5–9 age-group in Manduar and 17·6% in the 2–4 group in Keneba. 86% of all the children under the age of five who were HBsAg- positive also carried hepatitis Beantigen (HBeAg). This proportion fell to 17·6% for children aged 10–14 years and to 12·9% for mothers. Infection clustered in families, tra,smission from sib to sib being of major importance. The chances of a child being an HBsAg carrier were approximately 42% if an elder sib carried the antigen, 27% if either mother or father was a carrier, and 15% if neither mother or father was a carrier. There were 4 HBeAg-positive mothers who were highly infectious, since 10 of 11 of their children became HBsAg carriers. Carriage of surface antigen lasted many yaears; 63% of those carrying the antigen in 1972 were still positive in late 1980. 4 cases of primary hepatocellular carcinoma out of 672 adults have been diagnosed in the past five years. All 4 were in HBsAg carriers.