Role of clothing in skin exposure to di(n-butyl) phthalate and tris(1-chloro-2-propyl) phosphate: Experimental observations via skin wipes
Role of clothing in skin exposure to di(n-butyl) phthalate and tris(1-chloro-2-propyl) phosphate: Experimental observations via skin wipes
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衣服在皮肤暴露于邻苯二甲酸二正丁酯和磷酸三(1-氯-2-丙基)酯中的作用：通过皮肤擦拭布进行的实验观察
DOI：
10.1021/acs.estlett.0c00993
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发表时间：
2021
影响因子：
10.9
通讯作者：
Yinping Zhang
中科院分区：
文献类型：
--
作者：
Ningrui Liu;Jianping Cao;Jing Huang;Yinping Zhang
皮肤暴露是人体暴露于半挥发性有机化合物（SVOCs）的重要途径。现有的研究已经证明，衣服可以阻碍或加剧皮肤暴露于SVOCs。服装的作用受两个因素影响：服装条件（服装中的SVOC浓度）和皮肤与服装的接触形式（直接和间接接触）。为了揭示这两个因素的共同作用，进行了一系列的3小时暴露实验，涉及三名参与者。选择了室内环境中常见的两种SVOCs，邻苯二甲酸二丁酯（DnBP，增塑剂）和磷酸三（1-氯-2-丙基）酯（TCPP，磷系阻燃剂）作为目标污染物。皮肤擦拭法用于收集皮肤表面的SVOCs量，以反映皮肤暴露于SVOCs的水平。结果表明，已被DnBP和TCPP污染的服装（SVOC污染服装）明显加重皮肤暴露，而“干净”服装（不含DnBP和TCPP）则有明显的阻碍作用。皮肤与服装的直接接触倾向于维持服装状态对皮肤暴露的影响，而间接接触倾向于削弱服装状态对皮肤暴露的影响。本研究将有助于了解服装对皮肤暴露于SVOCs的影响。
Skin exposure is an important pathway for exposure of humans to semivolatile organic compounds (SVOCs). Existing studies have proven that clothing can either impede or aggravate skin exposure to SVOCs. The role of clothing is affected by two factors: clothing conditions (SVOC concentrations in clothing) and skin-to-clothing contact forms (direct and indirect contact). To reveal the co-effects of these two factors, a series of 3 h exposure experiments involving three participants were conducted. Two SVOCs commonly found in indoor environments, di(n-butyl) phthalate (DnBP, plasticizer) and tris(1-chloro-2-propyl) phosphate (TCPP, phosphorus flame retardant), were selected as the target pollutants. The skin-wipe method was used to collect the amount of SVOCs on the skin surface to reflect the levels of skin exposure to SVOCs. The results indicated that the clothing already contaminated by DnBP and TCPP (SVOC-contaminated clothing) significantly aggravated skin exposure while the “clean” clothing (free of DnBP and TCPP) had significant impeding effects. Skin-to-clothing direct contact tends to maintain the effects of clothing condition on skin exposure, while indirect contact tends to weaken the effects of clothing condition. This study should be helpful for understanding the impacts of clothing on skin exposure to SVOCs.