Dorsal striatum and stimulus-response learning: Lesions of the dorsolateral, but not dorsomedial, striatum impair acquisition of a stimulus-response-based instrumental discrimination task, while sparing conditioned place preference learning
Dorsal striatum and stimulus-response learning: Lesions of the dorsolateral, but not dorsomedial, striatum impair acquisition of a stimulus-response-based instrumental discrimination task, while sparing conditioned place preference learning
复制标题
DOI：
10.1016/j.neuroscience.2003.10.038
复制
发表时间：
2004-01-01
期刊：
影响因子：
3.3
通讯作者：
McDonald, RJ
中科院分区：
文献类型：
--
作者：
Featherstone, RE;McDonald, RJ
虽然一些证据表明，背侧纹状体是重要的刺激-反应学习，背外侧和背内侧纹状体的相对贡献存在分歧，这种形式的学习。在本实验中，背外侧和背内侧纹状体的病变的影响进行了研究，差异需要发展的刺激-反应学习的两个任务。第一个任务利用操作性条件判别任务，这可能在很大程度上依赖于刺激-反应学习。第二项任务看起来是条件性位置偏好学习，这是一项不太可能需要刺激-反应关联发展的任务。背外侧纹状体病变的动物受损的操作性条件歧视任务，但保留了学习条件位置偏好任务的能力。相反，背内侧纹状体病变的动物在本实验中使用的任何任务上都没有被发现受损。这些结果表明，背外侧纹状体是必要的成功收购的任务，刺激-反应学习的需求，而背内侧纹状体是不参与这种类型的学习。(C)2004年IBRO。由爱思唯尔有限公司出版。保留所有权利。
While some evidence suggests that the dorsal striatum is important for stimulus-response learning, disagreement exists about the relative contribution of the dorsolateral and dorsomedial striatum to this form of learning. In the present experiment, the effects of lesions of the dorsolateral and dorsomedial striatum were investigated on two tasks that differentially require the development of stimulus-response learning. The first task utilized an operant conditional discrimination task, which is likely to rely heavily upon stimulus-response learning. The second task looked conditioned place preference learning, a task that is unlikely to require the development of stimulus-response associations. Animals with lesions of the dorsolateral striatum were impaired on the operant conditional discrimination task, but retained the ability to learn the conditioned place preference task. In contrast, animals with lesions of the dorsomedial striatum were not found to be impaired on either task used in the present experiment. These results suggest that the dorsolateral striatum is necessary for the successful acquisition of tasks that place a demand upon stimulus-response learning, while the dorsomedial striatum is not involved in this type of learning. (C) 2004 IBRO. Published by Elsevier Ltd. All rights reserved.