Naturalizing mouse models for immunology
Naturalizing mouse models for immunology
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DOI：
10.1038/s41590-020-00857-2
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发表时间：
2021-02-01
影响因子：
30.5
通讯作者：
Graham, Andrea L.
中科院分区：
文献类型：
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作者：
Graham, Andrea L.
实验室小鼠为了解哺乳动物免疫系统提供了宝贵的见解。然而，在传统实验室条件下饲养和维持的小鼠的免疫表型通常与野生哺乳动物的免疫表型不同。最近通过建立暴露历史、提供粪便移植或野生小鼠代孕以及野化等方法，将近交实验小鼠的环境体验自然化，将它们带到野生动物所在的地方（借用莫里斯·森达克（Maurice Sendak）的一句话），这将扩大人们的理解，补充关于自然选择如何塑造哺乳动物免疫系统的遗传和系统发育研究，同时提高转化潜力。 小鼠研究。动物模型为了解免疫系统的功能提供了宝贵的见解；然而，它们也有其局限性。安德里亚·格雷厄姆 (Andrea Graham) 在《透视》中认为，使用更自然化的生物和非生物环境有助于更准确地了解免疫系统。
Laboratory mice have provided invaluable insight into mammalian immune systems. Yet the immune phenotypes of mice bred and maintained in conventional laboratory conditions often differ from the immune phenotypes of wild mammals. Recent work to naturalize the environmental experience of inbred laboratory mice-to take them where the wild things are (to borrow a phrase from Maurice Sendak), via approaches such as construction of exposure histories, provision of fecal transplants or surrogate mothering by wild mice, and rewilding-is poised to expand understanding, complementing genetic and phylogenetic research on how natural selection has shaped mammalian immune systems while improving the translational potential of mouse research.Animal models provide invaluable insights into the functioning of the immune system; however, they have their limitations. In a Perspective, Andrea Graham argues that using a more naturalized biotic and abiotic setting can help capture a more accurate picture of the immune system.