Right parietal activation during delusional state in episodic interictal psychosis of epilepsy: A report of two cases
Right parietal activation during delusional state in episodic interictal psychosis of epilepsy: A report of two cases
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DOI：
10.1016/j.yebeh.2006.06.017
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发表时间：
2006-09-01
影响因子：
2.6
通讯作者：
Takeda, M.
中科院分区：
文献类型：
--
作者：
Ishii, R.;Canuet, L.;Takeda, M.
脑磁图（MEG）被用来成像与癫痫发作间期精神病妄想相关的脑活动。对两名年龄分别为65岁和68岁的颞叶癫痫女性患者在妄想状态期间和之后进行了研究。过度峰度（g2）的地形图图像，尖峰活动的统计指标，从非平均的MEG记录使用一种称为“合成孔径磁强计”（SAM）的分析。对于这两名患者，MEG波形和过度峰度图像显示，在妄想状态下，在右下顶叶区域的尖峰活动。抗精神病药物治疗后，妄想症状消失，第二次脑磁图测量显示右顶叶区域无过度峰度。同样，脑磁图记录上的尖波也消失了。我们的研究结果表明，包括缘上回在内的右下顶叶皮层与癫痫发作间期精神病的妄想状态有关。(C)2006年爱思唯尔公司All rights reserved.
Magnetoencephalography (MEG) was used to image brain activity associated with delusions in episodic interictal psychosis of epilepsy. Two female patients aged 65 and 68 with temporal lobe epilepsy were studied during and after a delusional state. Topographic images of the excess kurtosis (g2), the statistical index of spikelike activity, were obtained from unaveraged MEG recordings using an analysis called "synthetic aperture magnetometry" (SAM). For both patients, MEG waveforms and excess kurtosis images revealed spiky activity in the right inferior parietal region during the delusional state. A second MEG measurement after delusions were resolved with antipsychotic therapy revealed no excess kurtosis in the right parietal area. Likewise, the sharp waves on MEG recordings disappeared as well. Our results suggest association of the right inferior parietal cortex, including the supramarginal gyrus, with the delusional state of episodic interictal psychosis of epilepsy. (C) 2006 Elsevier Inc. All rights reserved.