Citrinin dimers from the halotolerant fungus Penicillium citrinum B-57
Citrinin dimers from the halotolerant fungus Penicillium citrinum B-57
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来自耐盐真菌 Penicillium citrinum B-57 的柑橘素二聚体
DOI：
10.1021/np0704708
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发表时间：
2008-04-01
影响因子：
5.1
通讯作者：
Zhu, Wei-Ming
中科院分区：
文献类型：
--
作者：
Lu, Zhen-Yu;Lin, Zhen-Jian;Zhu, Wei-Ming
为了从微生物中寻找结构新颖、具有生物活性的天然化合物，从吉兰泰盐场沉积物中分离到一株主要产生桔霉素衍生物的耐盐真菌Penicillium citrinum B-57。从桔青霉B-57的乙酸乙酯提取物中分离得到两个新的桔霉素二聚体，即青霉烯酮C（1）和青霉烯醇B（2），以及11个已知的相关化合物。这些化合物显示出对DPPH自由基的抗氧化活性，IC 50值范围为0.8至59 μ M。
In order to search for structurally novel and bioactive natural compounds from microorganisms, a halotolerant fungal strain, Penicillium citrinum B-57, which mainly produces citrinin derivatives, was isolated from sediments collected from the Jilantai salt field. From the ethyl acetate extract of P. citrinum B-57, two new citrinin dimers, pennicitrinone C (1) and penicitrinol B (2), and I I known related compounds were isolated and identified by spectroscopic and chemical methods. These compounds showed antioxidative activity against DPPH radicals with IC50 values ranging from 0.8 to 59 mu M.