The sleep-feeding conflict: Understanding behavioral integration through genetic analysis in Drosophila.
The sleep-feeding conflict: Understanding behavioral integration through genetic analysis in Drosophila.
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DOI：
10.18632/aging.100181
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Keene AC
中科院分区：
文献类型：
--
作者：
McDonald DM;Keene AC
One of the brain's most important functions is the control of homeostatically regulated behaviors. Dysregulation of the neural systems controlling sleep and feeding underlies many chronic illnesses. In a recent study published inCurrent Biology we showed that flies, like mammals, suppress sleep when starved and identified the genes Clock and cycle as regulators of sleep during starvation. Here we show that starvation specifically disrupts sleep initiation without affecting sleep consolidation. The identification of genes regulating sleep-feeding interactions will provide insight into how the brain integrates and controls the expression of complex behaviors.
