MDA-7/IL-24: multifunctional cancer killing cytokine.
MDA-7/IL-24: multifunctional cancer killing cytokine.
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DOI：
10.1007/978-1-4471-6458-6_6
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发表时间：
2014
影响因子：
--
通讯作者：
Fisher PB
中科院分区：
文献类型：
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作者：
Menezes ME;Bhatia S;Bhoopathi P;Das SK;Emdad L;Dasgupta S;Dent P;Wang XY;Sarkar D;Fisher PB
MDA-7/IL-24 大约二十年前首次被鉴定为在诱导终末分化的人类黑色素瘤细胞中差异表达的新基因，此后显示出作为抗癌基因的巨大潜力。 MDA-7/IL24 是 IL-10 家族的一种分泌蛋白，在正常生理水平下充当细胞因子，并在免疫系统组织中表达。在超生理水平上，MDA-7/IL-24 在抑制肿瘤生长、侵袭、转移和血管生成方面发挥着重要作用，最近被证明可以靶向肿瘤干/起始细胞进行死亡。 MDA-7/IL-24之所以受到关注，是因为它可以选择性诱导癌细胞死亡，而不影响正常细胞。因此，该基因最初被证明与黑色素瘤细胞分化相关，现在已被证明是一种影响多种癌症的多功能蛋白质。此外，MDA-7/IL-24 在针对患有多种晚期癌症的人类的 I/II 期临床试验中已被证明是有效的。随着该领域研究的进展，我们将揭示 MDA-7/IL-24 的更多功能，并定义利用 MDA-7/IL-24 治疗癌症的新方法。
First identified almost two decades ago as a novel gene differentially expressed in human melanoma cells induced to terminally differentiate, MDA-7/IL-24 has since shown great potential as an anti-cancer gene. MDA-7/IL24, a secreted protein of the IL-10 family, functions as a cytokine at normal physiological levels and is expressed in tissues of the immune system. At supra-physiological levels, MDA-7/IL-24 plays a prominent role in inhibiting tumor growth, invasion, metastasis and angiogenesis and was recently shown to target tumor stem/initiating cells for death. Much of the attention focused on MDA-7/IL-24 originated from the fact that it can selectively induce cell death in cancer cells without affecting normal cells. Thus, this gene originally shown to be associated with melanoma cell differentiation has now proven to be a multi-functional protein affecting a broad array of cancers. Moreover, MDA-7/IL-24 has proven efficacious in a Phase I/II clinical trial in humans with multiple advanced cancers. As research in the field progresses, we will unravel more of the functions of MDA-7/IL-24 and define novel ways to utilize MDA-7/IL-24 in the treatment of cancer.