Neonatal exposure to an inflammatory cytokine, epidermal growth factor, results in the deficits of mismatch negativity in rats
Neonatal exposure to an inflammatory cytokine, epidermal growth factor, results in the deficits of mismatch negativity in rats
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DOI：
10.1038/s41598-019-43923-y
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发表时间：
2019-05-16
影响因子：
4.6
通讯作者：
Nawa, Hiroyuki
中科院分区：
文献类型：
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作者：
Jodo, Eiichi;Inaba, Hiroyoshi;Nawa, Hiroyuki
围产期暴露于表皮生长因子（EGF）诱导非人类动物成熟后的各种认知和行为异常，并用于精神分裂症的动物模型。精神分裂症患者常表现出失匹配负波（MMN）降低，这是一种刺激变化特异性事件相关脑电位。EGF模型动物是否也表现出精神分裂症患者的MMN减少？本研究旨在验证该模型的病理生理学有效性。新生大鼠接受EGF或生理盐水的重复给药，并生长至成年。采用不同音调的奇数球范例，从清醒大鼠的听觉和额叶皮层上的电极记录音调诱发的脑电图（EEG）成分，参考额窦上的电极。EGF处理组大鼠的MMN样电位的幅度明显低于生理盐水对照组。小波分析的EEG在近一段时间的音调刺激显示，同步的EEG活动，特别是与β和γ波段，减少EGF治疗的大鼠。结果表明，动物暴露于EGF在围产期作为一个有前途的精神分裂症的神经发育模型。
Perinatal exposure to epidermal growth factor (EGF) induces various cognitive and behavioral abnormalities after maturation in non-human animals, and is used for animal models of schizophrenia. Patients with schizophrenia often display a reduction of mismatch negativity (MMN), which is a stimulus-change specific event-related brain potential. Do the EGF model animals also exhibit the MMN reduction as schizophrenic patients do? This study addressed this question to verify the pathophysiological validity of this model. Neonatal rats received repeated administration of EGF or saline and were grown until adulthood. Employing the odd-ball paradigm of distinct tone pitches, tone-evoked electroencephalogram (EEG) components were recorded from electrodes on the auditory and frontal cortices of awake rats, referencing an electrode on the frontal sinus. The amplitude of the MMN-like potential was significantly reduced in EGF-treated rats compared with saline-injected control rats. The wavelet analysis of the EEG during a near period of tone stimulation revealed that synchronization of EEG activity, especially with beta and gamma bands, was reduced in EGF-treated rats. Results suggest that animals exposed to EGF during a perinatal period serve as a promising neurodevelopmental model of schizophrenia.