KINETIC CHARACTERISTICS OF BETA-CAROTENE UPTAKE AND DEPLETION IN RAT-TISSUE
KINETIC CHARACTERISTICS OF BETA-CAROTENE UPTAKE AND DEPLETION IN RAT-TISSUE
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DOI：
10.1093/jn/114.10.1924
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发表时间：
1984-01-01
影响因子：
4.2
通讯作者：
MACHLIN, LJ
中科院分区：
文献类型：
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作者：
SHAPIRO, SS;MOTT, DJ;MACHLIN, LJ
给大鼠喂食补充有0、0.002、0.02和0.2% β-淀粉酶的半纯化饮食。胡萝卜素（BC）21周，然后是5周的耗竭期。在不同时间点，分析肝脏、肾上腺、卵巢、肺、心脏、肾脏、血浆、皮肤、脑和肌肉的BC含量。在摄入的BC和BC组织含量之间发现了剂量反应效应。在饲喂0.2%BC饲料的动物中测定了BC的组织饱和水平和达到饱和的时间。还测定了BC的半衰期。组织含量、吸收率和消耗率之间无明显关系。研究的每个组织都不同。在脂肪中没有BC向我们暗示BC分布不仅仅是沉积到脂质库中的问题。BC的组织水平范围很宽;肝脏具有最大值，为50 μ g/g组织，肌肉具有最低值，为0.03 μ g/g组织。血浆在3天内达到饱和，而肝脏、肾上腺和卵巢在147天时尚未达到饱和。血浆中的半衰期<3天，肌肉中的半衰期为18天。
Rats were fed a semi-purified diet supplemented with 0, 0.002, 0.02 and 0.2% .beta.-carotene (BC) for 21 wk, followed by a 5-wk depletion period. At various time points liver, adrenal, ovary, lung, heart, kidney, plasma, skin, brain and muscle were analyzed for BC content. A dose-response effect between ingested BC and BC tissue content was found. The tissue saturation levels of BC, and time to reach saturation were determined in animals fed 0.2% BC diets. The half-life for BC was also determined. There was no apparent relationship among tissue content, rate of uptake and rate of depletion of BC. Each tissue studied was different. The absence of BC in fat suggests to us that BC distribution is not simply a matter of deposition into lipid depots. There was a wide range in tissue levels of BC; liver had the greatest value with 50 .mu.g/g tissue, and muscle had the lowest value with 0.03 .mu.g/g tissue. Plasma was saturated within 3 days, whereas liver, adrenal and ovary had not yet reached saturation at 147 days. The half-life varied from < 3 days for plasma to 18 days for muscle.