IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools
IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools
复制标题
DOI：
10.1093/nar/26.1.205
复制
发表时间：
1998-01-01
影响因子：
14.9
通讯作者：
Montesano, R
中科院分区：
文献类型：
--
作者：
Hainaut, P;Hernandez, T;Montesano, R
自1989年以来，在8000多种人类癌症中发现了约570种不同的p53突变。这些突变的数据库由M. Hollstein和C. C.哈里斯，1990年。该数据库最初由人类肿瘤和细胞系的p53基因中的体细胞点突变列表组成，从已发表的文献中编译并以标准电子形式提供，该数据库由国际癌症研究机构（IARC）维护，每年发布两次（1月和7月）更新版本。当前版本（1997年7月）包含6800个已发表突变的记录，并将在1998年1月发布时超过8000个标记，该数据库现在以新的格式包含关于体细胞和种系突变的信息，以便于数据检索，此外，还构建了新的工具来改进数据分析，例如欧洲生物信息学研究所（EBI）开发的Mutation Viewer Java小程序，用于可视化突变对p53蛋白质结构的位置和影响，该数据库在IARC以不同的电子格式提供（http：//www.iarc.fr/p53/homepage.htm）或从EBI服务器（www.ebi.ac.uk）。IARC p53网站还提供了数据库分析报告以及与其他p53网站和相关数据库的链接。在本报告中，我们描述了纳入数据的标准、修订后的格式和新的可视化工具。我们还简要讨论了p53突变的临床和生物学问题的相关性。
Since 1989 about 570 different p53 mutations have been identified in more than 8000 human cancers. A database of these mutations was initiated by M. Hollstein and C. C. Harris in 1990. This database originally consisted of a list of somatic point mutations in the p53 gene of human tumors and cell lines, compiled from the published literature and made available in a standard electronic form, The database is maintained at the International Agency for Research on Cancer (IARC) and updated versions are released twice a year (January and July). The current version (July 1997) contains records on 6800 published mutations and will surpass the 8000 mark in the January 1998 release, The database now contains information on somatic and germline mutations in a new format to facilitate data retrieval, In addition, new tools are constructed to improve data analysis, such as a Mutation Viewer Java applet developed at the European Bioinformatics Institute (EBI) to visualise the location and impact of mutations on p53 protein structure, The database is available in different electronic formats at IARC (http://www.iarc.fr/p53/homepage.htm) or from the EBI server (http://www.ebi.ac.uk). The IARC p53 website also provides reports on database analysis and links with other p53 sites as well as with related databases, In this report, we describe the criteria for inclusion of data, the revised format and the new visualisation tools. We also briefly discuss the relevance of p53 mutations to clinical and biological questions.