Microwave-assisted extraction of artemisinin from Artemisia annua L
Microwave-assisted extraction of artemisinin from Artemisia annua L
复制标题
DOI：
10.1016/s1383-5866(02)00043-6
复制
发表时间：
2002-09-01
影响因子：
8.6
通讯作者：
Deng, X
中科院分区：
文献类型：
--
作者：
Hao, JY;Han, W;Deng, X
采用微波辅助萃取法从黄花蒿中提取青蒿素。在MAE中使用了几种溶剂，如乙醇、三氯甲烷、环己烷、正己烷、石油醚（30-60 ℃）、石油醚（60-90 ℃）、120号溶剂油和6号萃取溶剂油。结果表明，6号萃取溶剂油是本实验的最佳溶剂。结果表明，青蒿素的提取率随研磨度、剂料比和正己烷与环己烷混合溶剂的介电常数的增加而增加。微波辅助提取青蒿素的最佳工艺条件为：微波辐射时间12 min，原料粒径小于0.125 mm，剂料比大于11.3。通过与索氏提取法、超临界CO2萃取法和常规搅拌萃取法的比较，研究了青蒿素的微波辅助提取工艺。一年生植物的提取时间短，提取率高。微波辅助提取时间仅为12 min，提取率为92.1%，而索氏提取法和常规搅拌提取法需要数小时，提取率仅为60%左右。超临界CO_2萃取的萃取物颜色最浅，但萃取率最低。(C)2002 Elsevier Science B. V.保留所有权利。
A new method of microwave-assisted extraction (MAE) is used to extract artemisinin from Artemisia annua L. Several solvents were used in MAE such as ethanol, trichloromethane, cyclohexane, n-hexane, petroleum ether (30-60 degreesC), petroleum ether (60-90 degreesC), No. 120 solvent oil and No. 6 extraction solvent oil. Results show that No. 6 extraction solvent oil is the best solvent in the experiments. It is well discussed that the extraction rate of artemisinin is increased with the increase of grinding degree, solvent to material ratio and dielectric constant of solvent mixed by hexane and cyclohexane. Optimal conditions of MAE of artemisinin can be concluded that the duration of microwave radiation is 12 min, the diameter of raw materials is less than 0.125 mm, the solvent to material ratio is more than 11.3. Compared with Soxhlet method, supercritical CO2 extraction and normal stirring extraction, MAE of artemisinin from A. annua L saves a lot of time, but gives the high extraction rate. The time used in MAE is only 12 min with 92.1% extraction rate, while Soxhlet method and normal stirring extraction need several hours with only about 60% extraction rate. Supercritical CO2 extraction gives the lightest color of extractive but lowest extraction rate. (C) 2002 Elsevier Science B.V. All rights reserved.