Fatigue and health-related quality of life (HRQL) in chronic hepatitis C virus infection
Fatigue and health-related quality of life (HRQL) in chronic hepatitis C virus infection
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DOI：
10.1007/s10620-006-9708-x
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发表时间：
2007-10-01
影响因子：
3.1
通讯作者：
Younossi, Zobair M.
中科院分区：
文献类型：
--
作者：
Kallman, Jillian;O'Neil, Mary Margaret;Younossi, Zobair M.
除慢性肝炎外，许多感染丙型肝炎病毒（HCV）的人还患有疲劳，这可能会影响他们的健康相关生活质量（HRQL）。系统评估慢性丙型肝炎患者的健康相关生活质量（HRQL），并确定是否有任何临床、生化、病毒学、人口统计学和组织学特征与HRQL状态相关。在这项横断面观察性研究中，130例慢性HCV感染患者（PCR检测HCV RNA阳性）和61例健康对照者来自三级护理教学医学中心。所有患者和对照组均完成一份通用HRQL问卷（MOS SF-36）和一份肝病特异性问卷（慢性肝病问卷，CLDQ）。95名HCV患者和所有对照者还完成了疲劳问卷（慢性疲劳筛查，CFS），并测定了免疫学标志物（冷球蛋白，可溶性IL-2受体，风湿因子）。我们将HCV感染患者的HRQL与对照组进行了比较，并使用其他研究的数据与普通人群、糖尿病患者和慢性腰痛患者进行了比较。慢性丙型肝炎患者HRQL受损程度高于健康对照组和II型糖尿病患者。疲劳是影响HRQL的最主要症状。61%的HCV感染患者报告了与疲劳相关的活动减少。此外，与HRQL相关的其他因素是性别和组织学肝硬化。慢性HCV感染对患者的HRQL有深远的负面影响。致残性疲劳是导致这一相对年轻的患者群体丧失幸福感的最重要因素。
In addition to chronic hepatitis, many individuals infected with hepatitis C virus (HCV) suffer from fatigue, which may compromise their health-related quality of life (HRQL). To assess systematically health-related quality of life (HRQL) in patients with chronic hepatitis C and to determine if any clinical, biochemical, virologic, demographic, and histologic features are associated with HRQL status. In this cross-sectional observational study, one hundred thirty patients with chronic HCV infection (HCV RNA positive by PCR) and 61 healthy controls were enrolled from a tertiary care teaching medical center. All patients and controls completed one generic HRQL questionnaire (MOS SF-36) and one liver-disease specific instrument (Chronic Liver Disease Questionnaire, CLDQ). Ninety-five HCV patients and all the controls also completed a fatigue questionnaire (Chronic Fatigue Screener, CFS) and had immunologic markers determined (Cryoglobulin, Soluble IL-2 receptors, Rheumatoid Factor). We compared the HRQL of HCV-infected patients to the controls and, using data from other studies, to the general population, patients with diabetes, and patients with chronic low back pain. Patients with chronic HCV had greater HRQL impairment than healthy controls and those with type II diabetes. Fatigue was the most important symptom with negative impact on HRQL. Sixty-one percent of HCV-infected patients reported fatigue-related loss of activity. Additionally, other factors associated with HRQL were gender and histologic cirrhosis. Chronic HCV infection has a profound negative impact on patients' HRQL. Disabling fatigue is the most important factor that contributes to loss of well-being in this relatively young group of patients.