Cigarette smoking and site-specific cancer mortality: testing uncertain associations using extended follow-up of the original Whitehall study
Cigarette smoking and site-specific cancer mortality: testing uncertain associations using extended follow-up of the original Whitehall study
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DOI：
10.1093/annonc/mdm578
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发表时间：
2008-05-01
影响因子：
50.5
通讯作者：
Shipley, M. J.
中科院分区：
文献类型：
--
作者：
Batty, G. D.;Kivimaki, M.;Shipley, M. J.
背景：吸烟与几种恶性肿瘤的关系尚不清楚。我们研究了吸烟与15个癌症部位死亡的关系，其中7个被认为与烟草有不确定的关系。患者和方法：最初的白厅研究是一个前瞻性队列，包括17363名伦敦的男性政府雇员（年龄40-69岁），他们在20世纪60年代末接受了检查，然后随访了最长38年。在对人口统计学特征、风险因素和流行疾病进行调整后，肺癌、胃癌、胰腺癌、膀胱癌、上呼吸消化道癌（包括食道癌）和肝癌以及髓性白血病的已建立的阳性吸烟-癌症梯度得到证实。在与吸烟关系不确定的癌症中，结肠、直肠和前列腺恶性肿瘤以及淋巴白血病的死亡率在目前和/或以前吸烟者中升高。有基本上没有明显的关系，吸烟和死亡率从脑癌或从lymphocyte.Conclusion：在这项研究中，吸烟似乎是一个危险因素，以前不清楚与烟草使用的几种恶性肿瘤。
Background: The relation between cigarette smoking and several malignancies is still unclear. We examined the association of cigarette smoking with death attributed to 15 cancer sites, 7 of which are regarded as having an uncertain relation with tobacco.Patients and methods: The original Whitehall study is a prospective cohort of 17 363 London-based male government employees (age 40-69 years) who were examined in the late 1960s and then followed up for a maximum of 38 years.Results: Following adjustment for demographic characteristics, risk factors, and prevalent disease, established positive cigarette smoking-cancer gradients were confirmed for carcinoma of the lung, stomach, pancreas, bladder, upper aero-digestive (including oesophagus), and liver, and for myeloid leukaemia. Among the cancers of uncertain relation with smoking, mortality rates for malignancy of the colon, rectum and prostate and for lymphatic leukaemia were elevated in current and/or former smokers. There was essentially no apparent relation between smoking and mortality from carcinoma of the brain or from lymphoma.Conclusion: In this study, cigarette smoking appears to be a risk factor for several malignancies of previously unclear association with tobacco use.