Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy
Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy
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DOI：
10.1161/01.cir.0000135591.37759.af
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发表时间：
2004-07-13
期刊：
影响因子：
37.8
通讯作者：
Granzier, HL
中科院分区：
文献类型：
--
作者：
Nagueh, SF;Shah, G;Granzier, HL
背景-巨蛋白肌联蛋白在心力衰竭患者中的作用尚未完全确定。我们研究了非缺血性扩张型心肌病导致的终末期心力衰竭患者的肌联蛋白表达，特别是它与左心室（LV）心肌僵硬度和LV功能的关系。方法和结果-SDS-琼脂糖凝胶显示小N2 B（僵硬）和大N2 BA（顺应）心脏肌联蛋白亚型，平均N2 BA：N2 B表达比显著（P
Background-The role of the giant protein titin in patients with heart failure is not well established. We investigated titin expression in patients with end-stage heart failure resulting from nonischemic dilated cardiomyopathy, in particular as it relates to left ventricular (LV) myocardial stiffness and LV function.Methods and Results-SDS-agarose gels revealed small N2B (stiff) and large N2BA ( compliant) cardiac titin isoforms with a mean N2BA: N2B expression ratio that was significantly (P