A single-blinded, randomized, controlled clinical trial evaluating the effect of face washing on acne vulgaris
A single-blinded, randomized, controlled clinical trial evaluating the effect of face washing on acne vulgaris
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DOI：
10.1111/j.1525-1470.2006.00276.x
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发表时间：
2006-09-01
影响因子：
1.5
通讯作者：
Kimball, Alexa B.
中科院分区：
文献类型：
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作者：
Choi, Joanna Mimi;Lew, Vincent K.;Kimball, Alexa B.
尽管人们普遍建议每天用温和的洗面奶洗脸两次，但几乎没有公开的证据支持这种做法。事实上，虽然公众认为清洁的皮肤会减少雀斑，但皮肤科医生经常警告说，过度清洗和擦洗会加剧这种情况。为了明确洗脸频率对寻常痤疮的影响，我们设计了一项单盲、随机、对照的临床试验，对男性轻度至中度寻常痤疮进行研究。受试者每天用标准的温和洗面奶洗脸两次，持续两周，然后随机分为三组，每天洗脸一次、两次或四次，持续六周。在研究结束时，两组之间没有统计学上的显著差异。然而，在每天清洗两次的组中，开放性粉刺和总非炎性病变均有显著改善。在研究组中观察到痤疮状况恶化，每天洗一次，红斑、丘疹和总炎性病变显著增加。我们的结论是，在功效和便利性方面，每天用温和的洗面奶洗脸两次的建议都有轻微的支持。然而，过度洗脸可能并不像之前认为的那样有罪。
Despite the common recommendation to wash the face twice daily with a mild cleanser, there is little published evidence to support the practice. Indeed, while the general public believes that cleaner skin will result in fewer blemishes, dermatologists often warn that overwashing and scrubbing can exacerbate the condition. To clarify the effect of frequency of face washing on acne vulgaris, we designed a single-blinded, randomized, controlled clinical trial to be conducted on males with mild to moderate acne vulgaris. Subjects washed their faces twice daily for 2 weeks with a standard mild cleanser before being randomized to one of three study arms, in which face washing was to be done once, twice, or four times a day for 6 weeks. At the end of the study no statistically significant differences were noted between groups. However, significant improvements in both open comedones and total noninflammatory lesions were observed in the group washing twice a day. Worsening of acne condition was observed in the study group washing once a day, with significant increases in erythema, papules, and total inflammatory lesions. We concluded that slight support exists, both in terms of efficacy and convenience, for the recommendation to wash the face twice daily with a mild cleanser. However, excessive face washing may not be as culpable as previously thought.