REACTIONS WITHIN CONSECUTIVE VASCULAR SECTIONS OF SMALL-INTESTINE OF CAT DURING PROLONGED HYPOTENSION
REACTIONS WITHIN CONSECUTIVE VASCULAR SECTIONS OF SMALL-INTESTINE OF CAT DURING PROLONGED HYPOTENSION
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DOI：
10.1111/j.1748-1716.1972.tb05166.x
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发表时间：
1972-01-01
期刊：
影响因子：
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通讯作者：
LUNDGREN, O
中科院分区：
文献类型：
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作者：
HAGLUND, U;LUNDGREN, O
采用体积描记技术来研究分级动脉闭塞产生约 55 或 30 mm Hg 的局部动脉低血压期间和之后 2-3 小时内猫小肠连续血管切片内的反应。肠道的交感神经被切断。低血压期间阻力血管扩张，灌注压越低扩张越明显。在低血压的早期阶段，肠道血流的这种自动调节可能主要是“肌源性的”，而在低血压的后期，它主要是“代谢性的”。当解除动脉闭塞时，55毫米汞柱低血压后血流恢复到控制，而30毫米汞柱低血压后观察到明显延长的血管舒张。在 55 mm Hg 的低血压期间，毛细血管滤过系数与对照相比没有变化，而在 30 mm Hg 时毛细血管滤过系数则有所增强。在该水平下进行的大多数实验的后半段，平均毛细管静水压似乎有所增加。低血压后似乎出现了额外的、短暂的毛细血管压力升高。低血压 30 毫米汞柱后松开动脉钳后，根据动脉血压的下降来判断，整个心血管系统似乎逐渐紊乱。
A plethysmography technique was utilized to investigate the reactions within consecutive vascular sections of the small intestine of the cat during and after a 2–3 h local arterial hypotension at approximately 55 or 30 mm Hg produced by graded arterial occlusion. The sympathetic nerves to the intestine were cut. The resistance vessels were dilated during hypotension, the dilatation being more pronounced the lower the perfusion pressure. In the early phase of hypotension this autoregulation of intestinal blood flow was probably mainly “myogenic” while it was predominantly “metabolic” in the late part of hypotension. When releasing the arterial occlusion, blood flow returned to control after a 55 mm Hg hypotension, while a marked prolonged vasodilatation was observed after the 30 mm Hg hypotension. The capillary filtration coefficient was not changed from control during a hypotension at 55 mm Hg while it was enhanced at 30 mm Hg. Mean capillary hydrostatic pressure seemed to increase in the latter half of most experiments performed at this level. An additional, transient augmentation of capillary pressure seemed to occur after the hypotension. Upon releasing the arterial clamp after a 30 mm Hg hypotension the whole cardiovascular system seemed to derange progressively to judge by a decline of arterial blood pressure.