Endocrine disruption by dietary phyto-oestrogens: impact on dimorphic sexual systems and behaviours.
Endocrine disruption by dietary phyto-oestrogens: impact on dimorphic sexual systems and behaviours.
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DOI：
10.1017/s0029665116000677
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发表时间：
2017-05
期刊：
影响因子：
--
通讯作者：
Patisaul HB
中科院分区：
文献类型：
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作者：
Patisaul HB
大豆摄入量对健康有广泛的益处，包括降低骨质疏松症、心脏病、乳腺癌和更年期症状的风险。然而，由于大豆是一种生殖活性饮食，它也可能干扰内分泌，这表明在某些情况下摄入大豆有可能对健康产生不利影响，特别是在发育期间接触大豆时。因此，大豆植物雌激素对人类健康是有益还是有害的问题既不简单，也不普遍适用于所有群体。可能的益处和风险取决于年龄，健康状况，甚至是否存在特定的肠道微生物菌群。随着全球消费量的增加，营养专家和其他卫生从业人员需要更多地认识和考虑大豆干扰内分泌的特性。婴儿和幼儿的消费特别令人关切，因为他们对生殖系统敏感的器官，包括大脑和生殖系统，仍处于性别分化和成熟阶段。因此，它们对大豆植物雌激素的内分泌干扰活性的敏感性可能特别高。作为雌激素受体部分激动剂，其分子和细胞特性与双酚A等人为内分泌干扰物相似，大豆植物雌激素提供了一个有趣的模型，说明对“合成”与“天然”的态度如何塑造对化合物内分泌干扰和/或潜在有害的理解和感知。本文综述了大豆植物雌激素的内分泌干扰特性，重点是神经内分泌发育和行为。
A wide range of health benefits have been ascribed to soya intake including a lowered risk of osteoporosis, heart disease, breast cancer, and menopausal symptoms. Because it is a hormonally active diet, however, soya can also be endocrine disrupting, suggesting that intake has the potential to cause adverse health effects in certain circumstances, particularly when exposure occurs during development. Consequently, the question of whether or not soya phyto-oestrogens are beneficial or harmful to human health is neither straightforward nor universally applicable to all groups. Possible benefits and risks depend on age, health status, and even the presence or absence of specific gut microflora. As global consumption increases, greater awareness and consideration of the endocrine-disrupting properties of soya by nutrition specialists and other health practitioners is needed. Consumption by infants and small children is of particular concern because their hormone-sensitive organs, including the brain and reproductive system, are still undergoing sexual differentiation and maturation. Thus, their susceptibility to the endocrine-disrupting activities of soya phyto-oestrogens may be especially high. As oestrogen receptor partial agonists with molecular and cellular properties similar to anthropogenic endocrine disruptors such as bisphenol A, the soya phyto-oestrogens provide an interesting model for how attitudes about what is ‘synthetic’ v. what is ‘natural,’ shapes understanding and perception of what it means for a compound to be endocrine disrupting and/or potentially harmful. This review describes the endocrine-disrupting properties of soya phyto-oestrogens with a focus on neuroendocrine development and behaviour.