Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1
Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1
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DOI：
10.1016/s0896-6273(01)80047-7
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发表时间：
1997-01-01
期刊：
影响因子：
16.2
通讯作者：
Tonegawa, S
中科院分区：
文献类型：
--
作者：
Kano, M;Hashimoto, K;Tonegawa, S
成年动物的大多数小脑浦肯野细胞 (PC) 均由单个攀爬纤维 (CF) 单独支配，该攀爬纤维与 PC 形成强兴奋性突触。 PC 和 CF 之间的这种一对一关系是 CF 对 PC 神经支配的发育调节回归的结果。我们发现，在缺乏 1 型代谢型谷氨酸受体 (mGluR1) 的小鼠中，多余 CF 的消退在出生后第二周结束时停止，这比正常小鼠早大约一周。因此，mGluR1 突变小鼠中约三分之一的 PC 在成年期受到多个 CF 的神经支配。我们得出的结论是，CF 的退化通常发生在两个发育阶段，并且 mGluR1 在第二阶段起着至关重要的作用。
Most of the cerebellar Purkinje cells (PCs) of an adult animal are innervated individually by a single climbing fiber (CF) that forms strong excitatory synapses with the PCs. This one-to-one relationship between a PC and a CF is a consequence of a developmentally regulated regression of the innervation of PCs by CFs. We found that, in mice deficient in the type 1 metabotropic glutamate receptor (mGluR1), the regression of supernumerary CFs ceases by the end of the second postnatal week, which is about one week earlier than in normal mice. Consequently, about one third of PCs in the mGluR1 mutant mice are innervated by multiple CFs in adulthood. We conclude that the regression of CFs normally occurs in two developmental phases and that mGluR1 plays a crucial role in the second phase.