Identification of two new HLA-A 1101-restricted tax epitopes recognized by cytotoxic T lymphocytes in an adult T-cell leukemia patient after hematopoietic stem cell transplantation
Identification of two new HLA-A 1101-restricted tax epitopes recognized by cytotoxic T lymphocytes in an adult T-cell leukemia patient after hematopoietic stem cell transplantation
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DOI：
10.1128/jvi.79.15.10088-10092.2005
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发表时间：
2005-08-01
影响因子：
5.4
通讯作者：
Kannagi, M
中科院分区：
文献类型：
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作者：
Harashima, N;Tanosaki, R;Kannagi, M
受HLA-A2或A24限制，在异基因造血干细胞移植（HSCT）后而非移植前的部分成人T细胞白血病（ATL）患者的外周血单个核细胞（PBMC）中体外和体内扩增。在这里，我们证明了类似的Tax特异性CTL扩增在PBMC中从另一个后HSCT ATL患者没有HLA-A2或A24，其CTL同样识别两个新鉴定的表位，Tax 88 -96和Tax 272 -280，受HLA-A11限制，这表明这些免疫显性Tax表位存在于ATL患者体内。
restricted by HLA-A2 or A24, expanded in vitro and in vivo in peripheral blood mononuclear cells (PBMC) from some adult T-cell leukemia (ATL) patients after but not before allogeneic hematopoietic stem cell transplantation (HSCT). Here, we demonstrated similar Tax-specific CTL expansion in PBMC from another post-HSCT ATL patient without HLA-A2 or A24, whose CTLs equally recognized two newly identified epitopes, Tax88-96 and Tax272-280, restricted by HLA-A11, suggesting that these immunodominant Tax epitopes are present in the ATL patient in vivo.