Enteropathogenic E. coli, Salmonella, and Shigella: masters of host cell cytoskeletal exploitation.
Enteropathogenic E. coli, Salmonella, and Shigella: masters of host cell cytoskeletal exploitation.
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DOI：
10.3201/eid0502.990205
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发表时间：
1999-03
影响因子：
11.8
通讯作者：
Finlay, B B
中科院分区：
文献类型：
--
作者：
Goosney, D L;Knoechel, D G;Finlay, B B
细菌病原体已经进化出多种策略来利用宿主的细胞过程，以便它们能够生存和持续存在。通常，细菌必须非常紧密地粘附在细胞上并在细胞外介导其作用，或者它必须找到一种侵入宿主细胞并在细胞内生存的方法。无论哪种情况，病原体都会劫持宿主的细胞骨架。细胞骨架为细胞提供了灵活的框架，并参与介导从细胞形状和结构到程序性细胞死亡的多种细胞功能。改变宿主细胞骨架对于介导病原体粘附、入侵和细胞内运动至关重要。我们重点介绍致病性大肠杆菌、鼠伤寒沙门氏菌和福氏志贺氏菌发病机制的最新进展。每一个都说明了细菌病原体如何对宿主细胞骨架产生巨大影响。
Bacterial pathogens have evolved numerous strategies to exploit their host's cellular processes so that they can survive and persist. Often, a bacterium must adhere very tightly to the cells and mediate its effects extracellularly, or it must find a way to invade the host's cells and survive intracellularly. In either case, the pathogen hijacks the host's cytoskeleton. The cytoskeleton provides a flexible framework for the cell and is involved in mediating numerous cellular functions, from cell shape and structure to programmed cell death. Altering the host cytoskeleton is crucial for mediating pathogen adherence, invasion, and intracellular locomotion. We highlight recent advances in the pathogenesis of enteropathogenic Escherichia coli, Salmonella Typhimurium, and Shigella flexneri. Each illustrates how bacterial pathogens can exert dramatic effects on the host cytoskeleton.