Elevated Risk for Sessile Serrated Polyps in African Americans with Endometrial Polyps
Elevated Risk for Sessile Serrated Polyps in African Americans with Endometrial Polyps
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DOI：
10.1007/s10620-019-05991-y
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发表时间：
2020-09-01
影响因子：
3.1
通讯作者：
Brim, Hassan
中科院分区：
文献类型：
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作者：
Ashktorab, Hassan;Sherif, Zaki;Brim, Hassan
结直肠和子宫内膜病变随着年龄的增长而增加。目前尚不清楚这两种前体病变在散发病例中是否相互关联。目的探讨非裔美国人结直肠息肉与子宫内膜息肉（EP）的关系。方法回顾2004年1月至2015年12月在霍华德大学医院妇科门诊和结肠镜检查的患者记录。我们将病例定义为所有EP患者并接受结肠镜检查。作为对照，我们选择了接受结肠镜检查的无ep患者。采用Logistic回归分析评估结肠息肉与EP之间的关系。结果118例患者中位年龄为60岁，对照组664例患者中位年龄为57岁。两组总体结肠直肠息肉患病率无统计学差异（对照组54%，病例52%，P = 0.60）。无柄锯齿状腺瘤/息肉（ssp）在病例中更为常见（8% vs.对照组2%，P = 0.003）。乙状结肠和直肠部位在对照组中比在病例中更普遍。在多因素分析中，在调整年龄、糖尿病（DM）和BMI后，ssp与EP发生相关，比值比为4.6 （CI 1.2-16.7,P = 0.022）。结论EP患者与未EP患者结肠直肠息肉患病率相似。然而，我们观察到EP患者的高危ssp之间存在显著关联。这些患者中吸烟和糖尿病的患病率较高。EP女性患者可能受益于与年龄无关的结肠病变筛查。
Background Colorectal and endometrial lesions increase with age. It is not known if these two precursor lesions in sporadic cases associate with each other. Aim To determine the association between colorectal polyps and endometrial polyps (EP) in African Americans. Methods We reviewed records of patients referred to gynecology clinics and had colonoscopy at Howard University Hospital from January 2004 to December 2015. We defined cases as all patients who had EP and underwent colonoscopy. For controls, we used EP-free patients who underwent colonoscopy. Logistic regression analysis was used to assess the association between colon polyps and EP. Results The median age was 60 years in 118 Cases and 57 years in 664 Controls. The overall colorectal polyps prevalence in the two groups was not statistically different (54% in controls vs. 52% in cases,P = 0.60). Sessile serrated adenoma/polyps (SSPs) were more frequent in cases (8% vs. 2% in controls,P = 0.003). Sigmoid and rectal locations were more prevalent in controls than cases. In multivariate analysis and after adjusting for age, diabetes mellitus (DM), and BMI, SSPs were associated with EP occurrence with an odds ratio of 4.6 (CI 1.2-16.7,P = 0.022). Conclusion Colorectal polyp prevalence was similar in EP patients compared to EP-free controls. However, we observed a significant association between higher-risk SSPs in patients with EP. The prevalence of smoking and DM was higher in these patients. Females with EP might benefit from a screening for colonic lesions in an age-independent manner.