EVALUATION OF THE CENTRAL EFFECTS OF ALCOHOL AND CAFFEINE INTERACTION
EVALUATION OF THE CENTRAL EFFECTS OF ALCOHOL AND CAFFEINE INTERACTION
复制标题
DOI：
10.1111/j.1365-2125.1995.tb04562.x
复制
发表时间：
1995-10-01
影响因子：
3.4
通讯作者：
JANE, F
中科院分区：
文献类型：
--
作者：
AZCONA, O;BARBANOJ, MJ;JANE, F
1在一项双盲、安慰剂对照、交叉试验中研究了酒精和咖啡因的动力学和动力学相互作用。在四个实验阶段中对八名健康受试者进行治疗，在每个实验阶段之间留出1周的洗脱期，如下：1）安慰剂，2）酒精（0.8 g kg（-1）），3）咖啡因（400 mg）和4）酒精（0.8 g kg（-1））+咖啡因（400 mg）。2通过以下方式进行评价：1）客观测量：a）心理表现（临界闪烁融合频率、简单反应时和敲击试验），B）长潜伏期视觉诱发电位（“模式反转”）; 2）主观自评量表（视觉模拟量表和情绪状态简介）; 3）咖啡因和酒精血浆浓度测定。3在基线和+0.5小时、+1.5小时、+2.5小时，+4小时和+6小时。对结果进行方差分析，接受P < 0.05为显著性。咖啡因和酒精的血浆-时间曲线通过模型独立方法进行分析。4客观测量中使用咖啡因获得的结果表明，简单反应时间减少，诱发电位幅度增加;受试者的自我评级显示出更活跃的趋势。酒精增加了简单反应时间，降低了诱发电位的幅度，尽管受试者认为自己很活跃。在客观测试中，酒精+咖啡因的组合与安慰剂没有显着差异;然而，醉酒的主观感觉仍然存在。当与酒精一起给药时，咖啡因的曲线下面积（AUC）显着更高。5只有那些证明咖啡因具有显着效果的客观测试才能检测到咖啡因对酒精的抵消作用。
1 The dynamic and kinetic interactions of alcohol and caffeine were studied in a double-blind, placebo controlled, cross-over trial. Treatments were administered to eight healthy subjects in four experimental sessions, leaving a 1 week wash-out period between each, as follows: 1) placebo, 2) alcohol (0.8 g kg(-1)), 3) caffeine (400 mg) and 4) alcohol (0.8 g kg(-1)) + caffeine (400 mg).2 Evaluations were performed by means of: 1) objective measures: a) psychomotor performance (critical flicker fusion frequency, simple reaction time and tapping test), b) long latency visual evoked potentials ('pattern reversal'); 2) subjective self-rated scales (visual analogue scales and profile of mood states); 3) caffeine and alcohol plasma concentration determinations.3 The battery of pharmacodynamic tests was conducted at baseline and at +0.5 h, +1.5 h, +2.5 h, +4 h and +6 h. An analysis of variance was applied to the results, accepting a P < 0.05 as significant. The plasma-time curves for caffeine and alcohol were analysed by means of model-independent methods.4 Results obtained with caffeine in the objective measures demonstrated a decrease in simple reaction time and an increase in the amplitude of the evoked potentials; the subjects' self-ratings showed a tendency to be more active. Alcohol increased simple reaction time and decreased amplitude of the evoked potentials, although the subjects rated themselves as being active. The combination of alcohol + caffeine showed no significant difference from placebo in the objective tests; nevertheless, the subjective feeling of drunkenness remained. The area under the curve (AUC) for caffeine was significantly higher when administered with alcohol.5 Only those objective tests which demonstrated a significant effect with caffeine were able to detect counteracting effects of caffeine over alcohol.