Wrangling Shape-Shifting Morpheeins to Tackle Disease and Approach Drug Discovery.
Wrangling Shape-Shifting Morpheeins to Tackle Disease and Approach Drug Discovery.
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DOI：
10.3389/fmolb.2020.582966
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发表时间：
2020
影响因子：
5
通讯作者：
Jaffe EK
中科院分区：
文献类型：
--
作者：
Jaffe EK
同源多聚体蛋白，可以分开，改变形状，并重新组装不同的功能后果已被称为morpheein和/或transformers;这些提供了一个很大程度上未开发的背景下了解疾病和发展变构疗法。本文在蛋白质结构动力学的背景下描述了此类蛋白质，提供了一个与先天性代谢错误和潜在除草剂开发相关的详细示例，并描述了应用这些想法来理解疾病和设计生物活性分子（例如治疗剂）的背景。
Homo-multimeric proteins that can come apart, change shape, and reassemble differently with functional consequences have been called morpheeins and/or transformers; these provide a largely unexplored context for understanding disease and developing allosteric therapeutics. This article describes such proteins within the context of protein structure dynamics, provides one detailed example related to an inborn error of metabolism and potential herbicide development, and describes the context for applying these ideas for understanding disease and designing bioactive molecules, such as therapeutics.
影响因子：
3.4
作者：
Lawrence, Sarah H.;Selwood, Trevor;Jaffe, Eileen K.
通讯作者：
Jaffe, Eileen K.