The Sox transcriptional factors: Functions during intestinal development in vertebrates.
The Sox transcriptional factors: Functions during intestinal development in vertebrates.
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DOI：
10.1016/j.semcdb.2016.08.022
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发表时间：
2017-03
影响因子：
7.3
通讯作者：
Shi YB
中科院分区：
文献类型：
--
作者：
Fu L;Shi YB
由于肠上皮通过成体肠干细胞的增殖进行终生自我更新，肠道长期以来一直被作为成体干细胞的模型进行研究。最近的证据表明，哺乳动物成体肠道干细胞的形成发生在甲状腺激素依赖性新生儿期，也称为胚胎后发育，类似于青蛙变态期间的肠道重塑。对非洲爪蟾变态的研究表明，Sox 家族（DNA 结合转录因子的一个大家族）的许多成员在肠干细胞的形成和/或增殖过程中在肠上皮中上调。同样，许多 Sox 基因与哺乳动物的肠道发育和发病机制有关。未来的研究需要确定这个重要基因家族在成体肠道干细胞发育中的表达和潜在参与。这些包括分析这些和其他 Sox 基因在哺乳动物胚胎后发育过程中的表达和调节，以及利用最近开发的基因敲除技术对哺乳动物和两栖动物进行功能研究。
The intestine has long been studied as a model for adult stem cells due to the life-long self-renewal of the intestinal epithelium through the proliferation of the adult intestinal stem cells. Recent evidence suggests that the formation of adult intestinal stem cells in mammals takes place during the thyroid hormone-dependent neonatal period, also known as postembryonic development, which resembles intestinal remodeling during frog metamorphosis. Studies on the metamorphosis in Xenopus laevis have revealed that many members of the Sox family, a large family of DNA binding transcription factors, are upregulated in the intestinal epithelium during the formation and/or proliferation of the intestinal stem cells. Similarly, a number of Sox genes have been implicated in intestinal development and pathogenesis in mammals. Futures studies are needed to determine the expression and potential involvement of this important gene family in the development of the adult intestinal stem cells. These include the analyses of the expression and regulation of these and other Sox genes during postembryonic development in mammals as well as functional investigations in both mammals and amphibians by using the recently developed gene knockout technologies.