Long-term rearrangements of hippocampal mossy fiber terminal connectivity in the adult regulated by experience
Long-term rearrangements of hippocampal mossy fiber terminal connectivity in the adult regulated by experience
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DOI：
10.1016/j.neuron.2006.04.026
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发表时间：
2006-06-01
期刊：
影响因子：
16.2
通讯作者：
Caroni, Pico
中科院分区：
文献类型：
--
作者：
Galimberti, Ivan;Gogolla, Nadine;Caroni, Pico
我们研究了海马苔藓纤维和CA3锥体神经元之间的连接重排。我们发现苔藓纤维在CA3内形成10-15个局部终末树枝状复合体(LMT-Cs)，这在成年小鼠的大小和发散方面显示出显著的差异。在成体中，LMT-Cs在连接性方面表现出两种类型的长期重排：LMT-C亚群在整个生命过程中沿着单个树突逐渐扩展，以及LMT-C复杂性随着丰富的环境而显著增加。在器官型切片培养中，LMT-Cs的亚群也进行了广泛的重排，并在数周和数月内生长，改变了先前存在的连接的强度，并建立或断开了与锥体神经元的连接。LMT-C可塑性的差异反映了单个LMT-Cs的特性，而不是苔藓纤维的特性。LMT-C的维持和生长受到尖峰活性、LMT释放mGluR2敏感递质和PKC的调节。因此，苔藓纤维形成的终末树枝复合体的亚群会根据一生中的经验和年龄重新安排它们的局部连接性。
We investigated rearrangements of connectivity between hippocampal mossy fibers and CA3 pyramidal neurons. We found that mossy fibers establish 10-15 local terminal arborization complexes (LMT-Cs) in CA3, which exhibit major differences in size and divergence in adult mice. LMT-Cs exhibited two types of long-term rearrangements in connectivity in the adult: progressive expansion of LMT-C subsets along individual dendrites throughout life, and pronounced increases in LMT-C complexities in response to an enriched environment. In organotypic slice cultures, subsets of LMT-Cs also rearranged extensively and grew over weeks and months, altering the strength of preexisting connectivity, and establishing or dismantling connections with pyramidal neurons. Differences in LMT-C plasticity reflected properties of individual LMT-Cs, not mossy fibers. LMT-C maintenance and growth were regulated by spiking activity, mGluR2-sensitive transmitter release from LMTs, and PKC. Thus, subsets of terminal arborization complexes by mossy fibers rearrange their local connectivities in response to experience and age throughout life.