Biased immunoglobulin light chain use in the Chlamydophila psittaci negative ocular adnexal marginal zone lymphomas.
Biased immunoglobulin light chain use in the Chlamydophila psittaci negative ocular adnexal marginal zone lymphomas.
复制标题
偏向免疫球蛋白轻链在鹦鹉热衣原体阴性眼附件边缘区淋巴瘤中的应用。
DOI：
10.1002/ajh.23416
复制
发表时间：
2013
影响因子：
12.8
通讯作者：
Lossos,IzidoreS
中科院分区：
文献类型：
--
作者：
Zhu,Daxing;Lossos,Chen;Chapman-Fredricks,JenniferR;Lossos,IzidoreS
Ocular adnexal mucosa associated lymphoid tissue lymphomas (OAMALTL) are the most common lymphomas of the eye. The potential roles for specific antigens in these lymphomas are still controversial. Previously we examinedIGHVusage and mutations inChlamydophila (C) psittaci‐negative OAMALTL, demonstrating biased use of theIGHV4family andIGHV4–34gene and evidence for antigen selection. Herein, we examined theIGKV/IGLVgene usage and mutations in 34C. psittaci‐negative OAMALTL originating from the orbit (15), conjunctivae (14), and lacrimal gland (5). Clonal potentially functionalIGKV/IGLVgene sequences were identified in 30 tumors (18 kappa and 12 lambda). An overrepresentation of the IGKV4 family (P< 0.01) was observed. The IGKV3–20*01 allele was used at a greater frequency than in normal peripheral blood B‐lymphocytes (P= 0.02) and commonly paired with the IGHV4–34 allele. Twenty‐seven of the 30 unique light chain sequences displayed mutations from germline and evidence for antigen selection. Overall our findings demonstrate that inC. psittaci‐negative OAMALTL there is a biased usage ofIGKVfamilies and genes, which harbor somatic mutations. These findings and the specific paring between the IGKV3–20*01 and IGHV4–34 alleles suggest that specific antigens could play an important role in the pathogenesis of these lymphomas. Am. J. Hematol. 88:379–384, 2013. © 2013 Wiley Periodicals, Inc.
