Association between local pulse pressure, mean blood pressure, and large-artery remodeling
Association between local pulse pressure, mean blood pressure, and large-artery remodeling
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DOI：
10.1161/01.cir.100.13.1387
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发表时间：
1999-09-28
期刊：
影响因子：
37.8
通讯作者：
Laurent, S
中科院分区：
文献类型：
--
作者：
Boutouyrie, P;Bussy, C;Laurent, S
背景-本研究的目的是确定局部脉压和平均血压对人类两个动脉部位动脉重构的影响：一条以弹性为主的中央动脉(颈总动脉)和一条外周肌肉动脉(桡动脉)。方法和结果--43名健康受试者和124名从未接受治疗的高血压患者纳入研究。使用高清晰度回声跟踪设备无创地测量颈动脉和桡动脉的内中膜厚度和内径。用压平眼压计测量局部脉压。建立全人群平均血压和局部脉压的多元回归模型。颈动脉内径和内-中膜厚度对颈动脉内径和内中膜厚度有显著影响(P
Background-The aim of the present study was to determine the respective influences of local pulse pressure and mean blood pressure on arterial remodeling in humans at 2 arterial sites: a central, predominantly elastic artery (the common carotid artery) and a peripheral muscular artery (the radial artery).Methods and Results-Forty-three healthy subjects and 124 never-treated hypertensive patients were included in the study. Intima-media thickness and internal diameter of the carotid and radial arteries were noninvasively determined with high-definition echo-tracking devices. Pulse pressure was measured locally with applanation tonometry. Multivariate regression models including mean blood pressure and local pulse pressure were established in the whole population. Carotid internal diameter and intima-media thickness were strongly influenced (P