Systematic review: generating evidence-based guidelines on the concurrent use of dietary antioxidants and chemotherapy or radiotherapy.

Systematic review: generating evidence-based guidelines on the concurrent use of dietary antioxidants and chemotherapy or radiotherapy.
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DOI:
10.3109/07357907.2011.626479
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发表时间:
2011-12
影响因子:
2.4
通讯作者:
White JD
White JD
中科院分区:
医学4区
文献类型:
--
作者:
Nakayama A;Alladin KP;Igbokwe O;White JD

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饮食抗氧化剂与化疗或放疗同时使用的风险效益比是一个有争议的话题。在这篇综述中,我们对同时使用抗氧化剂与化疗或放疗的医学文献进行了评估,并提出了进一步的循证指南。临床癌症研究界应该合作,并将新的研究重点放在抗氧化剂和化疗或放疗的特定组合的使用上,并确定特定癌症环境的最佳剂量。抗氧化剂和传统癌症治疗之间相互作用的机制研究可能会导致评估剂量充足性的新生物标志物。
The risk–benefit ratio for concurrent use of dietary antioxidants with chemotherapy or radiation therapy is a controversial topic. In this review, the medical literature on concurrent antioxidant use with chemotherapy or radiotherapy was assessed and further steps for generating evidence-based guidelines are suggested. The clinical cancer research community should cooperate and focus new studies on the use of a specific combination of antioxidant and chemotherapy or radiotherapy, and determine optimal doses for a specific cancer setting. Mechanistic studies on the interaction between antioxidants and conventional cancer therapy could lead to novel biomarkers for assessing dose adequacy.
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