Reverse pharmacology of orexin: from an orphan GPCR to integrative physiology
Reverse pharmacology of orexin: from an orphan GPCR to integrative physiology
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DOI：
10.1016/j.regpep.2004.08.006
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发表时间：
2005-03-15
影响因子：
--
通讯作者：
Sakurai, T
中科院分区：
文献类型：
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作者：
Sakurai, T
食欲素，最初被鉴定为两种孤儿G蛋白偶联受体（GPCR）的内源性肽配体。已经显示出在能量稳态的调节中具有重要作用。此外，在发作性睡病患者中发现食欲素缺乏表明食欲素是调节睡眠/觉醒的非常重要的因素。产生食欲素的神经元的传出和传入系统表明这些细胞与脑干中的唤醒中心以及下丘脑中的重要摄食中心之间的相互作用。电生理学研究表明，食欲素神经元受体液因素的调节，包括瘦素，葡萄糖，生长激素释放肽以及单胺和乙酰胆碱。因此，食欲素神经元与下丘脑摄食途径和单胺/胆碱能中心具有功能性相互作用，以提供外周能量平衡与协调睡眠/觉醒状态和动机行为（如寻找食物）的CNS机制之间的联系。(C)2004 Elsevier B. V.保留所有权利。
Orexins, which were initially identified as endogenous peptide ligands for two orphan G-protein coupled receptors (GPCRs). have been shown to have an important role in the regulation of energy homeostasis. Furthermore, the discovery of orexin deficiency in narcolepsy patients indicated that orexins are highly important factors for the sleep/wakefulness regulation. The efferent and afferent systems of orexin-producing neurons suggest interactions between these cells and arousal centers in the brainstem as well as important feeding centers in the hypothalamus. Electrophysiological Studies have shown that orexin neurons are regulated by humoral factors, including leptin, glucose, and ghrelin as well as monoamines and acetylcholin. Thus, orexin neurons have functional interactions with hypothalamic feeding pathways and monoamineraic/cholinergic centers to provide a link between peripheral energy balance and the CNS mechanisms that coordinate sleep/wakefulness states and motivated behavior such as food seeking. (C) 2004 Elsevier B.V. All rights reserved.