Lesions by tissue specific imaging characterize multiple sclerosis patients with more advanced disease
Lesions by tissue specific imaging characterize multiple sclerosis patients with more advanced disease
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DOI：
10.1177/1352458511414601
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发表时间：
2011-12-01
影响因子：
5.8
通讯作者：
Duyn, Jeff
中科院分区：
文献类型：
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作者：
Bagnato, Francesca;Ikonomidou, Vasiliki N.;Duyn, Jeff
背景资料：脑脊液组织特异性成像（CSF-TSI）是一种新的磁共振成像（MRI）技术，它可以显示慢性黑洞（cBH）的一个子集，其MRI特征提示存在CSF样液体，并代表具有广泛组织破坏的病变。目的：探讨多发性硬化（MS）患者CSF-TSI病变与疾病指标之间的关系。26例MS患者在3.0 T下进行了T1加权（T1-w）和T2-w自旋回波（SE）、T1体积图像和CSF-TSI图像。我们测量了：（i）T-1-w（cBH-LV）和T-2-w SE图像以及CSF-TSI中的病变体积（LV）;（ii）脑实质分数（BPF）。有和没有CSF-TSI病变的患者之间的差异进行了分析，临床和MRI metrics之间的关联进行了investigated.Results：cBH被认为是在92%的患者，而在CSF-TSI病变被认为是在40%。与无CSF-TSI病变的患者相比，有CSF-TSI病变的患者年龄更大，病程更长，残疾评分更高，cBH-LV和T-2-LV更大，BPF更低（
Background: Cerebrospinal fluid tissue specific imaging (CSF-TSI), a newly implemented magnetic resonance imaging (MRI) technique, allows visualization of a subset of chronic black holes (cBHs) with MRI characteristics suggestive of the presence of CSF-like fluid, and representing lesions with extensive tissue destruction.Objective: To investigate the relationship between lesions in CSF-TSI and disease measures in patients with multiple sclerosis (MS).Methods: Twenty-six patients with MS were imaged at 3.0 T, obtaining T-1-weighted (T-1-w) and T-2-w spin echo (SE), T-1 volumetric images and CSF-TSI images. We measured: (i) lesion volume (LV) in T-1-w (cBH-LV) and T-2-w SE images, and in CSF-TSI; (ii) brain parenchyma fraction (BPF). Differences between patients with and without CSF-TSI lesions were analyzed and association between clinical and MRI metrics were investigated.Results: cBHs were seen in 92% of the patients while lesions in CSF-TSI were seen in 40%. Patients with CSF-TSI lesions were older, with longer disease duration, higher disability scores, larger cBH-LV and T-2-LV, and lower BPF than patients without CSF-TSI lesions (