EFFECT OF VITAMIN A DEFICIENCY AND ESTROGEN ON UTERUS
EFFECT OF VITAMIN A DEFICIENCY AND ESTROGEN ON UTERUS
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DOI：
10.1093/ajcn/9.4.13
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发表时间：
1961-01-01
影响因子：
7.1
通讯作者：
BO, WJ
中科院分区：
文献类型：
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作者：
BO, WJ
雌激素处理大鼠的子宫上皮化生开始为许多独立的病灶，这些病灶生长并合并产生角化的复层鳞状上皮，其取代了原始的子宫上皮。由雌激素刺激引起的上皮化生的起源不同于维生素A缺乏时发生的化生，前者的变化发生在腔上皮，后者发生在子宫内膜腺体。由雌激素刺激产生的上皮比维生素A缺乏产生的上皮更厚，角质化更严重。观察到大鼠子宫角化化生仅发生在维生素A缺乏饮食的完整动物或接受雌激素治疗的卵巢切除、维生素A缺乏大鼠中。结果表明，雌激素在维生素A缺乏症中产生角化上皮中具有重要作用，并且不能认为这种变化仅是由于局部维生素A缺乏所致。从目前的调查，它可以得出结论，维生素A缺乏症是不是在大鼠子宫角化化生的主要因素，因为雌激素在产生的变化中发挥了作用。维生素A维持正常子宫上皮的作用方式尚不清楚，但似乎雌激素和维生素A之间可能存在平衡，以维持子宫上皮的完整性。当这种平衡被破坏时，就会发生角化化生。将维生素A缺乏大鼠阴道角化异常与子宫变化进行比较，得出两者不同的结论。在阴道中，这种变化更多的是一种增生性变化，而在子宫中，它是一种化生性变化。因此，从对维生素A缺乏症患者阴道以及维生素A和雌激素之间的观察中得出的结论不能推广到包括子宫。
Metaplasia of the uterine epithelium of estrogen-treated rats begins as many independent foci that grow and coalesce to produce a keratinized stratified squamous epithelium which replaced the original uterine epithelium. The origin of epithelial metaplasia produced by estrogen stimulation differs from the metaplasia which occurs in vitamin A deficiency in that in the former the change takes place in the luminal epithelium and the latter in the endometrial glands. The epithelium produced by estrogen stimulation is thicker and more heavily keratinized than that produced by vitamin A deficiency. Keratinizing metaplasia in the uterus of the rat was observed to occur only in intact animals on a vitamin A deficient diet or in the ovari-ectomized, vitamin A deficient rats treated with estrogen. The results demonstrated that estrogen has an important role in producing keratin- ized epithelium in avitaminosis A and the change cannot be considered to be due to only a local vitamin A deficiency. From the present investigation it can be concluded that vitamin A deficiency is not the primary factor in producing keratinizing metaplasia in the uterus of the rat since estrogen plays a role in producing the change. The mode of action of vitamin A in maintaining normal uterine epithelium is not known, but it seems that a balance may exist between estrogen and vitamin A in order to maintain the integrity of the uterine epithelium. When this balance is disrupted, keratinizing metaplasia occurs. The abnormal cornification of the vagina that occurs in vitamin A deficiency of the rat was compared with the uterine changes and it was concluded that the two are not the same. In the vagina the change is more of a hyperplastic change while in the uterus it is a metaplastic change. Therefore, the conclusions drawn from the observations made on the vagina in avitaminosis A and between vitamin A and estrogen cannot be generalized to include the uterus.